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Protein
Submitted name:

Map kinase phosphatase-M B2 isoform

Gene

Dusp16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • inactivation of MAPK activity Source: MGI
  • negative regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Map kinase phosphatase-M B2 isoformImported
Gene namesi
Name:Dusp16Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9AG15.

Structurei

3D structure databases

ProteinModelPortaliQ9AG15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 127106RhodaneseInterPro annotationAdd
BLAST
Domaini106 – 216111Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini172 – 22049TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG075427.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AG15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHEMIGTQI VTESLVALLE SGTEKVLLID SRPFVEYNTS HILEAININC
60 70 80 90 100
SKLMKRRLQQ DRVLITELIQ HSAKHKVDID CNQKVVVYDQ SSQDVGSLSS
110 120 130 140 150
DCFLTVLLGK LERSFNSVHL LADLMQQNGI GYVLNASNTC PKPDFIPESH
160 170 180 190 200
FLRVPVNDSF CEKILPWLDK SVDFIEKAKA SNGCVLIHCL AGISRSATIA
210 220 230 240 250
IAYIMKRMDM SLDEAYRRQK PTDRADSRRT GMKRAPLKSS LNAEAAKWNL
260 270 280 290 300
ERALCRRTGP GRSWARWAAS PASPAAWRSS RSLEKTSSLL LTVLFPVHKK
Length:300
Mass (Da):33,625
Last modified:June 1, 2001 - v1
Checksum:i4C61846ACDF0F456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345954 mRNA. Translation: AAK35055.1.
UniGeneiMm.491182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345954 mRNA. Translation: AAK35055.1.
UniGeneiMm.491182.

3D structure databases

ProteinModelPortaliQ9AG15.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9AG15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917936. Dusp16.

Phylogenomic databases

HOVERGENiHBG075427.

Miscellaneous databases

ChiTaRSiDusp16. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Novel MKP is an Important Negative Regulator of LPS-mediated JNK Activation in Macrophages."
    Matsuguchi T., Musikacharoen T., Johnson T.R., Kraft A.S., Yoshikai Y.
    Mol. Cell. Biol. 20:6999-7009(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.

Entry informationi

Entry nameiQ9AG15_MOUSE
AccessioniPrimary (citable) accession number: Q9AG15
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 17, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.