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Q9AFI1

- CPSD_STRA5

UniProt

Q9AFI1 - CPSD_STRA5

Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Dephosphorylated and activated by CpsB.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme regulator activity Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAGA208435:GHVY-1266-MONOMER.
    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase CpsD (EC:2.7.10.2)
    Gene namesi
    Name:cpsD
    Ordered Locus Names:SAG1172
    OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
    Taxonomic identifieri208435 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000821: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Tyrosine-protein kinase CpsDPRO_0000217236Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi208435.SAG1172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AFI1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsD/CapB family.Curated

    Phylogenomic databases

    eggNOGiCOG0489.
    HOGENOMiHOG000004334.
    OMAiRSIFSKF.
    OrthoDBiEOG69D3H6.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13614. AAA_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01007. eps_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9AFI1-1 [UniParc]FASTAAdd to Basket

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    MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS    50
    TASTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA 100
    DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII 150
    IDTPPIGLVV DAAIIANACD GFILVTQAGR IKRNYVEKAK EQMEQSGSKF 200
    LGIILNKVNE SVATYGDYGN YGKRDRKRK 229
    Length:229
    Mass (Da):25,064
    Last modified:January 17, 2003 - v2
    Checksum:i47806254BE6FC580
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2191G → GDYG1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349539 Genomic DNA. Translation: AAK29650.1.
    AE009948 Genomic DNA. Translation: AAN00054.1.
    RefSeqiNP_688181.1. NC_004116.1.

    Genome annotation databases

    EnsemblBacteriaiAAN00054; AAN00054; SAG1172.
    GeneIDi1013979.
    KEGGisag:SAG1172.
    PATRICi19629180. VBIStrAga72745_1178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349539 Genomic DNA. Translation: AAK29650.1 .
    AE009948 Genomic DNA. Translation: AAN00054.1 .
    RefSeqi NP_688181.1. NC_004116.1.

    3D structure databases

    ProteinModelPortali Q9AFI1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208435.SAG1172.

    Protocols and materials databases

    DNASUi 1013979.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN00054 ; AAN00054 ; SAG1172 .
    GeneIDi 1013979.
    KEGGi sag:SAG1172.
    PATRICi 19629180. VBIStrAga72745_1178.

    Phylogenomic databases

    eggNOGi COG0489.
    HOGENOMi HOG000004334.
    OMAi RSIFSKF.
    OrthoDBi EOG69D3H6.

    Enzyme and pathway databases

    UniPathwayi UPA00934 .
    BioCyci SAGA208435:GHVY-1266-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13614. AAA_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01007. eps_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence."
      McKinnon K., Chaffin D.O., Rubens C.E.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CNCTC 1/82 / Serotype V.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-611 / 2603 V/R.

    Entry informationi

    Entry nameiCPSD_STRA5
    AccessioniPrimary (citable) accession number: Q9AFI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3