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Q9AFI1

- CPSD_STRA5

UniProt

Q9AFI1 - CPSD_STRA5

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Protein
Tyrosine-protein kinase CpsD
Gene
cpsD, SAG1172
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB By similarity.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. enzyme regulator activity Source: InterPro
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1266-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Ordered Locus Names:SAG1172
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Tyrosine-protein kinase CpsD
PRO_0000217236Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi208435.SAG1172.

Structurei

3D structure databases

ProteinModelPortaliQ9AFI1.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000004334.
OMAiRSIFSKF.
OrthoDBiEOG69D3H6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AFI1-1 [UniParc]FASTAAdd to Basket

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MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS    50
TASTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA 100
DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII 150
IDTPPIGLVV DAAIIANACD GFILVTQAGR IKRNYVEKAK EQMEQSGSKF 200
LGIILNKVNE SVATYGDYGN YGKRDRKRK 229
Length:229
Mass (Da):25,064
Last modified:January 17, 2003 - v2
Checksum:i47806254BE6FC580
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191G → GDYG1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349539 Genomic DNA. Translation: AAK29650.1.
AE009948 Genomic DNA. Translation: AAN00054.1.
RefSeqiNP_688181.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAN00054; AAN00054; SAG1172.
GeneIDi1013979.
KEGGisag:SAG1172.
PATRICi19629180. VBIStrAga72745_1178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349539 Genomic DNA. Translation: AAK29650.1 .
AE009948 Genomic DNA. Translation: AAN00054.1 .
RefSeqi NP_688181.1. NC_004116.1.

3D structure databases

ProteinModelPortali Q9AFI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208435.SAG1172.

Protocols and materials databases

DNASUi 1013979.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN00054 ; AAN00054 ; SAG1172 .
GeneIDi 1013979.
KEGGi sag:SAG1172.
PATRICi 19629180. VBIStrAga72745_1178.

Phylogenomic databases

eggNOGi COG0489.
HOGENOMi HOG000004334.
OMAi RSIFSKF.
OrthoDBi EOG69D3H6.

Enzyme and pathway databases

UniPathwayi UPA00934 .
BioCyci SAGA208435:GHVY-1266-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13614. AAA_31. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01007. eps_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence."
    McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CNCTC 1/82 / Serotype V.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiCPSD_STRA5
AccessioniPrimary (citable) accession number: Q9AFI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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