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Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB.By similarity

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processCapsule biogenesis/degradation, Exopolysaccharide synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAGA208435:G1FZP-1267-MONOMER
UniPathwayiUPA00934

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Ordered Locus Names:SAG1172
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002172361 – 229Tyrosine-protein kinase CpsDAdd BLAST229

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9AFI1

Structurei

3D structure databases

ProteinModelPortaliQ9AFI1
SMRiQ9AFI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.Curated

Phylogenomic databases

HOGENOMiHOG000004334
OMAiRTNIEFT

Family and domain databases

InterProiView protein in InterPro
IPR025669 AAA_dom
IPR005702 EPS_synthesis
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13614 AAA_31, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01007 eps_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9AFI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS
60 70 80 90 100
TASTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA
110 120 130 140 150
DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII
160 170 180 190 200
IDTPPIGLVV DAAIIANACD GFILVTQAGR IKRNYVEKAK EQMEQSGSKF
210 220
LGIILNKVNE SVATYGDYGN YGKRDRKRK
Length:229
Mass (Da):25,064
Last modified:January 17, 2003 - v2
Checksum:i47806254BE6FC580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219G → GDYG (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349539 Genomic DNA Translation: AAK29650.1
AE009948 Genomic DNA Translation: AAN00054.1
RefSeqiNP_688181.1, NC_004116.1
WP_000197405.1, NC_004116.1

Genome annotation databases

EnsemblBacteriaiAAN00054; AAN00054; SAG1172
GeneIDi1013979
KEGGisag:SAG1172
PATRICifig|208435.3.peg.1178

Similar proteinsi

Entry informationi

Entry nameiCPSD_STRA5
AccessioniPrimary (citable) accession number: Q9AFI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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