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Q9AFI1 (CPSD_STRA5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase CpsD

EC=2.7.10.2
Gene names
Name:cpsD
Ordered Locus Names:SAG1172
OrganismStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) [Complete proteome] [HAMAP]
Taxonomic identifier208435 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation

Dephosphorylated and activated by CpsB By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the CpsD/CapB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Tyrosine-protein kinase CpsD
PRO_0000217236

Experimental info

Sequence conflict2191G → GDYG Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9AFI1 [UniParc].

Last modified January 17, 2003. Version 2.
Checksum: 47806254BE6FC580

FASTA22925,064
        10         20         30         40         50         60 
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS TASTSLALSL 

        70         80         90        100        110        120 
AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA DLGDIICETN VPRLMVVPSG 

       130        140        150        160        170        180 
KVPPNPTALL QNAYFNKMIE AIKNIFDYII IDTPPIGLVV DAAIIANACD GFILVTQAGR 

       190        200        210        220 
IKRNYVEKAK EQMEQSGSKF LGIILNKVNE SVATYGDYGN YGKRDRKRK 

« Hide

References

« Hide 'large scale' references
[1]"Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence."
McKinnon K., Chaffin D.O., Rubens C.E.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CNCTC 1/82 / Serotype V.
[2]"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae."
Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F. expand/collapse author list , Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-611 / 2603 V/R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF349539 Genomic DNA. Translation: AAK29650.1.
AE009948 Genomic DNA. Translation: AAN00054.1.
RefSeqNP_688181.1. NC_004116.1.

3D structure databases

ProteinModelPortalQ9AFI1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208435.SAG1172.

Protocols and materials databases

DNASU1013979.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN00054; AAN00054; SAG1172.
GeneID1013979.
KEGGsag:SAG1172.
PATRIC19629180. VBIStrAga72745_1178.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0489.
HOGENOMHOG000004334.
OMAGKYYGKY.
OrthoDBEOG69D3H6.
ProtClustDBCLSK883944.

Enzyme and pathway databases

BioCycSAGA208435:GHVY-1266-MONOMER.
UniPathwayUPA00934.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01007. eps_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSD_STRA5
AccessionPrimary (citable) accession number: Q9AFI1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways