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Reviewed, UniProtKB/Swiss-Prot Q9AFI1 (CPSD_STRA5)

Last modified November 3, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine-protein kinase cpsD
    EC=2.7.10.2
Gene names
Name: cpsD
Ordered Locus Names: SAG1172
OrganismStreptococcus agalactiae serotype V [Complete proteome] [HAMAP]
Taxonomic identifier216466 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of cpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation

Dephosphorylated and activated by cpsB By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the cpsD/capB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Tyrosine-protein kinase cpsD
PRO_0000217236

Experimental info

Sequence conflict2191G → GDYG Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9AFI1-1 [UniParc].

Last modified January 17, 2003. Version 2.
Checksum: 47806254BE6FC580

FASTA22925,064
        10         20         30         40         50         60 
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS TASTSLALSL 

        70         80         90        100        110        120 
AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA DLGDIICETN VPRLMVVPSG 

       130        140        150        160        170        180 
KVPPNPTALL QNAYFNKMIE AIKNIFDYII IDTPPIGLVV DAAIIANACD GFILVTQAGR 

       190        200        210        220 
IKRNYVEKAK EQMEQSGSKF LGIILNKVNE SVATYGDYGN YGKRDRKRK 

« Hide

References

« Hide 'large scale' references
[1]"Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence."
McKinnon K., Chaffin D.O., Rubens C.E.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CNCTC 1/82 / Serotype V.
[2]"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae."
Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F. expand/collapse author list , Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002) [PubMed: 12200547] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-611 / 2603 V/R / Serotype V.

Cross-references

Sequence databases

AF349539 Genomic DNA. Translation: AAK29650.1.
AE009948 Genomic DNA. Translation: AAN00054.1.
RefSeqNP_688181.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1013979.
GenomeReviewsGene locus SAG1172 in contig AE009948_GR.
KEGGsag:SAG1172.
TIGRSAG1172.

Phylogenomic databases

HOGENOMQ9AFI1.
OMANAIRTNI.

Family and domain databases

InterProIPR005702. EPS_synthesis.
[Graphical view]
TIGRFAMsTIGR01007. eps_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSD_STRA5
AccessionPrimary (citable) accession number: Q9AFI1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: November 3, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents