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Q9AEM9

- XFP_BIFAS

UniProt

Q9AEM9 - XFP_BIFAS

Protein

Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase

Gene

xfp

Organism
Bifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Phosphoketolase using both fructose 6-phosphate and xylulose 5-phosphate as substrate.

    Catalytic activityi

    D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.
    D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O.

    Cofactori

    Thiamine pyrophosphate.Curated

    Kineticsi

    1. KM=10 mM for fructose 6-phosphate
    2. KM=45 mM for xylulose 5-phosphate

    GO - Molecular functioni

    1. fructose-6-phosphate phosphoketolase activity Source: UniProtKB-EC
    2. phosphoketolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciBANI555970:GJ22-970-MONOMER.
    MetaCyc:MONOMER-12656.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (EC:4.1.2.22, EC:4.1.2.9)
    Gene namesi
    Name:xfp
    Ordered Locus Names:Balat_0971
    OrganismiBifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)
    Taxonomic identifieri555970 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000009076: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 825825Xylulose-5-phosphate/fructose-6-phosphate phosphoketolasePRO_0000193867Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.Curated

    Protein-protein interaction databases

    STRINGi555970.Balat_0971.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AEM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XFP family.Curated

    Phylogenomic databases

    eggNOGiCOG3957.
    HOGENOMiHOG000236450.
    KOiK01632.
    OMAiVYAHINR.
    OrthoDBiEOG61S2WD.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    HAMAPiMF_01403. Phosphoketolase.
    InterProiIPR023962. Phosphoketolase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005593. Xul5P/Fru6P_PKetolase.
    IPR018969. Xul5P/Fru6P_PKetolase_C.
    IPR019790. Xul5P/Fru6P_PKetolase_CS.
    IPR018970. Xul5P/Fru6P_PKetolase_N.
    IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
    [Graphical view]
    PfamiPF03894. XFP. 1 hit.
    PF09363. XFP_C. 1 hit.
    PF09364. XFP_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017245. Phosphoketolase. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    PROSITEiPS60002. PHOSPHOKETOLASE_1. 1 hit.
    PS60003. PHOSPHOKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9AEM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNPVIGTPW QKLDRPVSEE AIEGMDKYWR VANYMSIGQI YLRSNPLMKE    50
    PFTRDDVKHR LVGHWGTTPG LNFLLAHINR LIADHQQNTV FIMGPGHGGP 100
    AGTAQSYIDG TYTEYYPNIT KDEAGLQKFF RQFSYPGGIP SHFAPETPGS 150
    IHEGGELGYA LSHAYGAIMD NPSLFVPCII GDGEAETGPL ATGWQSNKLV 200
    NPRTDGIVLP ILHLNGYKIA NPTILARISD EELHDFFRGM GYHPYEFVAG 250
    FDNEDHLSIH RRFAELFETI FDEICDIKAA AQTDDMTRPF YPMLIFRTPK 300
    GWTCPKFIDG KKTEGSWRAH QVPLASARDT EAHFEVLKGW MESYKPEELF 350
    NADGSIKEDV TAFMPKGELR IGANPNANGG RIREDLKLPE LDQYEITGVK 400
    EYGHGWGQVE APRSLGAYCR DIIKNNPDSF RVFGPDETAS NRLNATYEVT 450
    KKQWDNGYLS ALVDENMAVT GQVVEQLSEH QCEGFLEAYL LTGRHGIWSS 500
    YESFVHVIDS MLNQHAKWLE ATVREIPWRK PISSVNLLVS SHVWRQDHNG 550
    FSHQDPGVTS VLLNKTFNND HVTNIYFATD ANMLLAIAEK CFKSTNKINA 600
    IFAGKQPAAT WITLDEVRAE LEAGAAEWKW ASNAKSNDEV QVVLAAAGDV 650
    PTQEIMAASD ALNKMGIKFK VVNVVDLIKL QSSKENDEAM SDEDFADLFT 700
    ADKPVLFAYH SYAQDVRGLI YDRPNHDNFT VVGYKEQGST TTPFDMVRVN 750
    DMDRYALQAK ALELIDADKY ADKINELNEF RKTAFQFAVD NGYDIPEFTD 800
    WVYPDVKVDE TSMLSATAAT AGDNE 825
    Length:825
    Mass (Da):92,530
    Last modified:June 1, 2001 - v1
    Checksum:iF1A418B84E7F97DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181S → V AA sequence (PubMed:11292814)Curated
    Sequence conflicti23 – 231E → I AA sequence (PubMed:11292814)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ293946 Genomic DNA. Translation: CAC29121.1.
    CP001606 Genomic DNA. Translation: ACS47899.1.
    RefSeqiWP_012754421.1. NC_012815.1.
    YP_002969961.1. NC_012815.1.

    Genome annotation databases

    EnsemblBacteriaiACS47899; ACS47899; Balat_0971.
    GeneIDi8010592.
    KEGGiblt:Balat_0971.
    PATRICi21111520. VBIBifAni93544_0969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ293946 Genomic DNA. Translation: CAC29121.1 .
    CP001606 Genomic DNA. Translation: ACS47899.1 .
    RefSeqi WP_012754421.1. NC_012815.1.
    YP_002969961.1. NC_012815.1.

    3D structure databases

    ProteinModelPortali Q9AEM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 555970.Balat_0971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS47899 ; ACS47899 ; Balat_0971 .
    GeneIDi 8010592.
    KEGGi blt:Balat_0971.
    PATRICi 21111520. VBIBifAni93544_0969.

    Phylogenomic databases

    eggNOGi COG3957.
    HOGENOMi HOG000236450.
    KOi K01632.
    OMAi VYAHINR.
    OrthoDBi EOG61S2WD.

    Enzyme and pathway databases

    BioCyci BANI555970:GJ22-970-MONOMER.
    MetaCyc:MONOMER-12656.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    HAMAPi MF_01403. Phosphoketolase.
    InterProi IPR023962. Phosphoketolase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005593. Xul5P/Fru6P_PKetolase.
    IPR018969. Xul5P/Fru6P_PKetolase_C.
    IPR019790. Xul5P/Fru6P_PKetolase_CS.
    IPR018970. Xul5P/Fru6P_PKetolase_N.
    IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
    [Graphical view ]
    Pfami PF03894. XFP. 1 hit.
    PF09363. XFP_C. 1 hit.
    PF09364. XFP_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017245. Phosphoketolase. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    PROSITEi PS60002. PHOSPHOKETOLASE_1. 1 hit.
    PS60003. PHOSPHOKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis."
      Meile L., Rohr L.M., Geissmann T.A., Herensperger M., Teuber M.
      J. Bacteriol. 183:2929-2936(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-31, CHARACTERIZATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10140 / JCM 10602 / LMG 18314.

    Entry informationi

    Entry nameiXFP_BIFAS
    AccessioniPrimary (citable) accession number: Q9AEM9
    Secondary accession number(s): C6AIU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3