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Q9AEM9 (XFP_BIFAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase
EC=4.1.2.22
EC=4.1.2.9
Gene names
Name:xfp
Ordered Locus Names:Balat_0971
OrganismBifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314) [Complete proteome] [HAMAP]
Taxonomic identifier555970 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium ›

Protein attributes

Sequence length825 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphoketolase using both fructose 6-phosphate and xylulose 5-phosphate as substrate. HAMAP-Rule MF_01403

Catalytic activity

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_01403

D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. HAMAP-Rule MF_01403

Cofactor

Thiamine pyrophosphate Potential.

Subunit structure

Homohexamer Probable.

Sequence similarities

Belongs to the XFP family.

Biophysicochemical properties

Kinetic parameters:

KM=10 mM for fructose 6-phosphate

KM=45 mM for xylulose 5-phosphate

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 825825Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase HAMAP-Rule MF_01403
PRO_0000193867

Experimental info

Sequence conflict181S → V AA sequence Ref.1
Sequence conflict231E → I AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9AEM9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F1A418B84E7F97DF

FASTA82592,530
        10         20         30         40         50         60 
MTNPVIGTPW QKLDRPVSEE AIEGMDKYWR VANYMSIGQI YLRSNPLMKE PFTRDDVKHR 

        70         80         90        100        110        120 
LVGHWGTTPG LNFLLAHINR LIADHQQNTV FIMGPGHGGP AGTAQSYIDG TYTEYYPNIT 

       130        140        150        160        170        180 
KDEAGLQKFF RQFSYPGGIP SHFAPETPGS IHEGGELGYA LSHAYGAIMD NPSLFVPCII 

       190        200        210        220        230        240 
GDGEAETGPL ATGWQSNKLV NPRTDGIVLP ILHLNGYKIA NPTILARISD EELHDFFRGM 

       250        260        270        280        290        300 
GYHPYEFVAG FDNEDHLSIH RRFAELFETI FDEICDIKAA AQTDDMTRPF YPMLIFRTPK 

       310        320        330        340        350        360 
GWTCPKFIDG KKTEGSWRAH QVPLASARDT EAHFEVLKGW MESYKPEELF NADGSIKEDV 

       370        380        390        400        410        420 
TAFMPKGELR IGANPNANGG RIREDLKLPE LDQYEITGVK EYGHGWGQVE APRSLGAYCR 

       430        440        450        460        470        480 
DIIKNNPDSF RVFGPDETAS NRLNATYEVT KKQWDNGYLS ALVDENMAVT GQVVEQLSEH 

       490        500        510        520        530        540 
QCEGFLEAYL LTGRHGIWSS YESFVHVIDS MLNQHAKWLE ATVREIPWRK PISSVNLLVS 

       550        560        570        580        590        600 
SHVWRQDHNG FSHQDPGVTS VLLNKTFNND HVTNIYFATD ANMLLAIAEK CFKSTNKINA 

       610        620        630        640        650        660 
IFAGKQPAAT WITLDEVRAE LEAGAAEWKW ASNAKSNDEV QVVLAAAGDV PTQEIMAASD 

       670        680        690        700        710        720 
ALNKMGIKFK VVNVVDLIKL QSSKENDEAM SDEDFADLFT ADKPVLFAYH SYAQDVRGLI 

       730        740        750        760        770        780 
YDRPNHDNFT VVGYKEQGST TTPFDMVRVN DMDRYALQAK ALELIDADKY ADKINELNEF 

       790        800        810        820 
RKTAFQFAVD NGYDIPEFTD WVYPDVKVDE TSMLSATAAT AGDNE

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis."
Meile L., Rohr L.M., Geissmann T.A., Herensperger M., Teuber M.
J. Bacteriol. 183:2929-2936(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-31, CHARACTERIZATION.
[2]"Comparison of the complete genome sequences of Bifidobacterium animalis subsp. lactis DSM 10140 and Bl-04."
Barrangou R., Briczinski E.P., Traeger L.L., Loquasto J.R., Richards M., Horvath P., Coute-Monvoisin A.-C., Leyer G., Rendulic S., Steele J.L., Broadbent J.R., Oberg T., Dudley E.G., Schuster S., Romero D.A., Roberts R.F.
J. Bacteriol. 191:4144-4151(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10140 / JCM 10602 / LMG 18314.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ293946 Genomic DNA. Translation: CAC29121.1.
CP001606 Genomic DNA. Translation: ACS47899.1.
RefSeqYP_002969961.1. NC_012815.1.

3D structure databases

ProteinModelPortalQ9AEM9.
ModBaseSearch...

Protein-protein interaction databases

STRING555970.Balat_0971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS47899; ACS47899; Balat_0971.
GeneID8010592.
KEGGblt:Balat_0971.
PATRIC21111520. VBIBifAni93544_0969.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3957.
HOGENOMHOG000236450.
KOK01632.
OMAADIVRIY.
ProtClustDBPRK05261.

Enzyme and pathway databases

BioCycBANI555970:GJ22-970-MONOMER.
MetaCyc:MONOMER-12656.

Family and domain databases

Gene3D3.40.50.920. 1 hit.
HAMAPMF_01403. Phosphoketolase.
InterProIPR023962. Phosphoketolase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view]
PfamPF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view]
PIRSFPIRSF017245. Phosphoketolase. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
PROSITEPS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
PS00187. TPP_ENZYMES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXFP_BIFAS
AccessionPrimary (citable) accession number: Q9AEM9
Secondary accession number(s): C6AIU2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents