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Q9AEM9

- XFP_BIFAS

UniProt

Q9AEM9 - XFP_BIFAS

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Protein

Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase

Gene

xfp

Organism
Bifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Phosphoketolase using both fructose 6-phosphate and xylulose 5-phosphate as substrate.

Catalytic activityi

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.
D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O.

Cofactori

Thiamine pyrophosphate.Curated

Kineticsi

  1. KM=10 mM for fructose 6-phosphate
  2. KM=45 mM for xylulose 5-phosphate

GO - Molecular functioni

  1. fructose-6-phosphate phosphoketolase activity Source: UniProtKB-EC
  2. phosphoketolase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBANI555970:GJ22-970-MONOMER.
MetaCyc:MONOMER-12656.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (EC:4.1.2.22, EC:4.1.2.9)
Gene namesi
Name:xfp
Ordered Locus Names:Balat_0971
OrganismiBifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)
Taxonomic identifieri555970 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000009076: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 825825Xylulose-5-phosphate/fructose-6-phosphate phosphoketolasePRO_0000193867Add
BLAST

Interactioni

Subunit structurei

Homohexamer.Curated

Protein-protein interaction databases

STRINGi555970.Balat_0971.

Structurei

3D structure databases

ProteinModelPortaliQ9AEM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XFP family.Curated

Phylogenomic databases

eggNOGiCOG3957.
HOGENOMiHOG000236450.
KOiK01632.
OMAiVYAHINR.
OrthoDBiEOG61S2WD.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
HAMAPiMF_01403. Phosphoketolase.
InterProiIPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view]
PfamiPF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017245. Phosphoketolase. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
PROSITEiPS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AEM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNPVIGTPW QKLDRPVSEE AIEGMDKYWR VANYMSIGQI YLRSNPLMKE
60 70 80 90 100
PFTRDDVKHR LVGHWGTTPG LNFLLAHINR LIADHQQNTV FIMGPGHGGP
110 120 130 140 150
AGTAQSYIDG TYTEYYPNIT KDEAGLQKFF RQFSYPGGIP SHFAPETPGS
160 170 180 190 200
IHEGGELGYA LSHAYGAIMD NPSLFVPCII GDGEAETGPL ATGWQSNKLV
210 220 230 240 250
NPRTDGIVLP ILHLNGYKIA NPTILARISD EELHDFFRGM GYHPYEFVAG
260 270 280 290 300
FDNEDHLSIH RRFAELFETI FDEICDIKAA AQTDDMTRPF YPMLIFRTPK
310 320 330 340 350
GWTCPKFIDG KKTEGSWRAH QVPLASARDT EAHFEVLKGW MESYKPEELF
360 370 380 390 400
NADGSIKEDV TAFMPKGELR IGANPNANGG RIREDLKLPE LDQYEITGVK
410 420 430 440 450
EYGHGWGQVE APRSLGAYCR DIIKNNPDSF RVFGPDETAS NRLNATYEVT
460 470 480 490 500
KKQWDNGYLS ALVDENMAVT GQVVEQLSEH QCEGFLEAYL LTGRHGIWSS
510 520 530 540 550
YESFVHVIDS MLNQHAKWLE ATVREIPWRK PISSVNLLVS SHVWRQDHNG
560 570 580 590 600
FSHQDPGVTS VLLNKTFNND HVTNIYFATD ANMLLAIAEK CFKSTNKINA
610 620 630 640 650
IFAGKQPAAT WITLDEVRAE LEAGAAEWKW ASNAKSNDEV QVVLAAAGDV
660 670 680 690 700
PTQEIMAASD ALNKMGIKFK VVNVVDLIKL QSSKENDEAM SDEDFADLFT
710 720 730 740 750
ADKPVLFAYH SYAQDVRGLI YDRPNHDNFT VVGYKEQGST TTPFDMVRVN
760 770 780 790 800
DMDRYALQAK ALELIDADKY ADKINELNEF RKTAFQFAVD NGYDIPEFTD
810 820
WVYPDVKVDE TSMLSATAAT AGDNE
Length:825
Mass (Da):92,530
Last modified:June 1, 2001 - v1
Checksum:iF1A418B84E7F97DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181S → V AA sequence (PubMed:11292814)Curated
Sequence conflicti23 – 231E → I AA sequence (PubMed:11292814)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293946 Genomic DNA. Translation: CAC29121.1.
CP001606 Genomic DNA. Translation: ACS47899.1.
RefSeqiWP_012754421.1. NC_012815.1.
YP_002969961.1. NC_012815.1.

Genome annotation databases

EnsemblBacteriaiACS47899; ACS47899; Balat_0971.
GeneIDi8010592.
KEGGiblt:Balat_0971.
PATRICi21111520. VBIBifAni93544_0969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293946 Genomic DNA. Translation: CAC29121.1 .
CP001606 Genomic DNA. Translation: ACS47899.1 .
RefSeqi WP_012754421.1. NC_012815.1.
YP_002969961.1. NC_012815.1.

3D structure databases

ProteinModelPortali Q9AEM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 555970.Balat_0971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS47899 ; ACS47899 ; Balat_0971 .
GeneIDi 8010592.
KEGGi blt:Balat_0971.
PATRICi 21111520. VBIBifAni93544_0969.

Phylogenomic databases

eggNOGi COG3957.
HOGENOMi HOG000236450.
KOi K01632.
OMAi VYAHINR.
OrthoDBi EOG61S2WD.

Enzyme and pathway databases

BioCyci BANI555970:GJ22-970-MONOMER.
MetaCyc:MONOMER-12656.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
HAMAPi MF_01403. Phosphoketolase.
InterProi IPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view ]
Pfami PF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF017245. Phosphoketolase. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
PROSITEi PS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis."
    Meile L., Rohr L.M., Geissmann T.A., Herensperger M., Teuber M.
    J. Bacteriol. 183:2929-2936(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-31, CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10140 / JCM 10602 / LMG 18314.

Entry informationi

Entry nameiXFP_BIFAS
AccessioniPrimary (citable) accession number: Q9AEM9
Secondary accession number(s): C6AIU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3