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Q9AEL8

- COX3_CORGL

UniProt

Q9AEL8 - COX3_CORGL

Protein

Cytochrome c oxidase subunit 3

Gene

ctaE

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Protein family/group databases

    TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 3
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:ctaE
    Ordered Locus Names:Cgl2192, cg2406
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Cytochrome c oxidase subunit 3PRO_0000183880Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with subunits I, II and IV to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with the menaquinol-cytochrome c reductase complex (cytochrome bc1).1 Publication

    Protein-protein interaction databases

    STRINGi196627.cg2406.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9AEL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    HOGENOMiHOG000086399.
    KOiK02276.
    OMAiFAFINTI.
    OrthoDBiEOG6SFPBZ.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9AEL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSAVGNTGM AAPQRVAALN RPNMVSVGTI VFLSQELMFF AGLFAMYFVS    50
    RANGLANGSW GEQTDHLNVP YALLITVILV SSSVTCQFGV FAAERGDVYG 100
    LRKWFLVTII LGSIFVIGQG YEYITLVGHG LTIQSSVYGS AFFITTGFHA 150
    LHVIAGVMAF VVVLMRIHKS KFTPAQATAA MVVSYYWHFV DVVWIGLFIT 200
    IYFIQ 205
    Length:205
    Mass (Da):22,442
    Last modified:June 1, 2001 - v1
    Checksum:i05EC548C01B45A63
    GO

    Mass spectrometryi

    Molecular mass is 22400.7±27.9 Da from positions 1 - 205. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306418 Genomic DNA. Translation: CAC33825.1.
    BA000036 Genomic DNA. Translation: BAB99585.1.
    BX927154 Genomic DNA. Translation: CAF20533.1.
    AB052749 Genomic DNA. Translation: BAB64408.1.
    RefSeqiNP_601396.2. NC_003450.3.
    WP_011014948.1. NC_006958.1.
    YP_226434.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99585; BAB99585; BAB99585.
    CAF20533; CAF20533; cg2406.
    GeneIDi1020144.
    KEGGicgb:cg2406.
    cgl:NCgl2112.
    PATRICi21496386. VBICorGlu203724_2129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306418 Genomic DNA. Translation: CAC33825.1 .
    BA000036 Genomic DNA. Translation: BAB99585.1 .
    BX927154 Genomic DNA. Translation: CAF20533.1 .
    AB052749 Genomic DNA. Translation: BAB64408.1 .
    RefSeqi NP_601396.2. NC_003450.3.
    WP_011014948.1. NC_006958.1.
    YP_226434.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q9AEL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg2406.

    Protein family/group databases

    TCDBi 3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99585 ; BAB99585 ; BAB99585 .
    CAF20533 ; CAF20533 ; cg2406 .
    GeneIDi 1020144.
    KEGGi cgb:cg2406.
    cgl:NCgl2112.
    PATRICi 21496386. VBICorGlu203724_2129.

    Phylogenomic databases

    eggNOGi COG1845.
    HOGENOMi HOG000086399.
    KOi K02276.
    OMAi FAFINTI.
    OrthoDBi EOG6SFPBZ.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the cytochrome bc1-aa3 branch of the Corynebacterium glutamicum respiratory chain containing an unusual diheme cytochrome c1."
      Niebisch A., Bott M.
      Arch. Microbiol. 175:282-294(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. "Cytochrome c oxidase contains an extra charged amino acid cluster in a new type of respiratory chain in the amino acid-producing Gram-positive bacterium Corynebacterium glutamicum."
      Sakamoto J., Shibata T., Mine T., Miyahara R., Torigoe T., Noguchi S., Matsushita K., Sone N.
      Microbiology 147:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, MASS SPECTROMETRY.
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    5. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
      Niebisch A., Bott M.
      J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiCOX3_CORGL
    AccessioniPrimary (citable) accession number: Q9AEL8
    Secondary accession number(s): Q79VE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3