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Q9AE11

- RUVC_CORGL

UniProt

Q9AE11 - RUVC_CORGL

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene
ruvC, Cgl1662, cg1871
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Magnesium By similarity
Metal bindingi73 – 731Magnesium By similarity
Metal bindingi146 – 1461Magnesium By similarity
Metal bindingi149 – 1491Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:Cgl1662, cg1871
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Crossover junction endodeoxyribonuclease RuvCUniRule annotationPRO_0000183093Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1871.

Structurei

3D structure databases

ProteinModelPortaliQ9AE11.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AE11-1 [UniParc]FASTAAdd to Basket

« Hide

MNHEGLRVMG IDPGLTRCGL SVVQAGRGRT VYPVSVGVVR TPPDAELAER    50
LLRLSKAVGE WMDEYTPDVI AIERVFERGN VSTVMNTAHA VGVLILAAAE 100
RGLPVHMYTP SEVKKAISGN GRADKKQMTV MITRILGLGE PPKPADAADA 150
LSLAVCHCWR APMLMRAQSQ YSEQELEKRR RVQQGKLGKA KSTYNAEQAQ 200
SHASDPAKAA HPSQFQRTDT N 221
Length:221
Mass (Da):24,097
Last modified:June 1, 2001 - v1
Checksum:iFA295C4D5704597D
GO

Sequence cautioni

The sequence CAF20044.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038651 Genomic DNA. Translation: AAK19838.1.
BA000036 Genomic DNA. Translation: BAB99055.1.
BX927153 Genomic DNA. Translation: CAF20044.1. Different initiation.
RefSeqiNP_600874.2. NC_003450.3.
WP_011014519.1. NC_003450.3.
YP_225945.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99055; BAB99055; BAB99055.
CAF20044; CAF20044; cg1871.
GeneIDi1019629.
KEGGicgb:cg1871.
cgl:NCgl1598.
PATRICi21495358. VBICorGlu203724_1622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038651 Genomic DNA. Translation: AAK19838.1 .
BA000036 Genomic DNA. Translation: BAB99055.1 .
BX927153 Genomic DNA. Translation: CAF20044.1 . Different initiation.
RefSeqi NP_600874.2. NC_003450.3.
WP_011014519.1. NC_003450.3.
YP_225945.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q9AE11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99055 ; BAB99055 ; BAB99055 .
CAF20044 ; CAF20044 ; cg1871 .
GeneIDi 1019629.
KEGGi cgb:cg1871.
cgl:NCgl1598.
PATRICi 21495358. VBICorGlu203724_1622.

Phylogenomic databases

eggNOGi COG0817.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of Corynebacterium glutamicum secretion genes secD, secF and secG in transporting the Streptomyces griseus alpha-amylase."
    Berens S., Kalinowski J., Puehler A.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiRUVC_CORGL
AccessioniPrimary (citable) accession number: Q9AE11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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