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Protein

HTH-type transcriptional repressor SCO4008

Gene

SCO4008

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably regulates the expression of its own gene and the adjacent SCO4007 gene by binding to two operator sites in the SCO4007-SCO4008 intergenic region.1 Publication

Enzyme regulationi

Binding of a wide range of cationic hydrophobic compounds to SCO4008 causes a decrease in DNA-binding, probably via allosteric conformational change of SCO4008.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 49H-T-H motifCuratedAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor SCO4008
Gene namesi
Ordered Locus Names:SCO4008
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267301 – 192HTH-type transcriptional repressor SCO4008Add BLAST192

Proteomic databases

PRIDEiQ9ADP7.

Expressioni

Inductioni

Autoregulated.1 Publication

Interactioni

Subunit structurei

Homodimer. Four dimers bind to the two operator sites.1 Publication

Protein-protein interaction databases

STRINGi100226.SCO4008.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 24Combined sources16
Turni25 – 27Combined sources3
Helixi31 – 38Combined sources8
Helixi42 – 49Combined sources8
Helixi52 – 70Combined sources19
Helixi75 – 77Combined sources3
Helixi78 – 91Combined sources14
Helixi94 – 106Combined sources13
Helixi114 – 133Combined sources20
Helixi143 – 159Combined sources17
Helixi161 – 168Combined sources8
Helixi171 – 190Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D6YX-ray2.30A/B1-192[»]
ProteinModelPortaliQ9ADP7.
SMRiQ9ADP7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ADP7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 67HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Domaini

Contains an N-terminal DNA-binding domain and a C-terminal dimerization domain.1 Publication

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000161261.
InParanoidiQ9ADP7.
OMAiFWEGMEY.
OrthoDBiPOG091H02BD.
PhylomeDBiQ9ADP7.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ADP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARDPEATK ARIFEAAVAE FARHGIAGAR IDRIAAEARA NKQLIYAYYG
60 70 80 90 100
NKGELFASVL EKKMLDLAIS VPVDPDDIEG WIDRLLDYHA AHPELLRLLF
110 120 130 140 150
WEGMEYGTAE LPHEAERQEH YARKVAAVRD GQERGVITDA IPAPDLLFLL
160 170 180 190
VAMANWAVVV PQMKRILVGG GDAGTDGLRD SIKKAARRIV DR
Length:192
Mass (Da):21,272
Last modified:June 1, 2001 - v1
Checksum:i93AA98FA74CA1E87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939118 Genomic DNA. Translation: CAC32348.1.
RefSeqiNP_628190.1. NC_003888.3.
WP_011029378.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC32348; CAC32348; CAC32348.
GeneIDi1099444.
KEGGisco:SCO4008.
PATRICi23737782. VBIStrCoe124346_4071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939118 Genomic DNA. Translation: CAC32348.1.
RefSeqiNP_628190.1. NC_003888.3.
WP_011029378.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D6YX-ray2.30A/B1-192[»]
ProteinModelPortaliQ9ADP7.
SMRiQ9ADP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4008.

Proteomic databases

PRIDEiQ9ADP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32348; CAC32348; CAC32348.
GeneIDi1099444.
KEGGisco:SCO4008.
PATRICi23737782. VBIStrCoe124346_4071.

Phylogenomic databases

HOGENOMiHOG000161261.
InParanoidiQ9ADP7.
OMAiFWEGMEY.
OrthoDBiPOG091H02BD.
PhylomeDBiQ9ADP7.

Miscellaneous databases

EvolutionaryTraceiQ9ADP7.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTHR_STRCO
AccessioniPrimary (citable) accession number: Q9ADP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.