Reviewed, UniProtKB/Swiss-Prot Q9ADA7 (GLPK1_STRCO)

Names and origin

Protein names

Recommended name:
    Glycerol kinase 1
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 1
    Glycerokinase 1
      Short name=GK 1

Gene names

Name:	glpK1
Ordered Locus Names:	SCO1660
ORF Names:	SCI52.02

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Glycerol kinase 1 HAMAP MF_00186		PRO_0000059502
Regions
	Nucleotide binding	422 – 426	5	ATP By similarity
Sites
	Binding site	18	1	Substrate By similarity
	Binding site	22	1	ATP By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	255	1	Substrate By similarity
	Binding site	277	1	ATP By similarity
	Binding site	321	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ADA7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: EE06E0EF603332AB	FASTA	512	55,985
	10 20 30 40 50 60 MTDSHTAGPF IAAIDQGTTS SRCIVFDRDG RIVSVDQKEH EQIFPKPGWV EHDATEIWTN 70 80 90 100 110 120 VQEVVAGAVE KAGITRDDIK AIGITNQRET TLVWDKNTGE PVHNAIVWQD TRTDALCKEL 130 140 150 160 170 180 GRNVGQDRFR RETGLPLASY FAGPKARWLL DNVDGLRERA EAGDLLFGTM DTWVIWNLTG 190 200 210 220 230 240 GVNGGKHVTD VTNASRTMLM NLHTMAWDEK IAESIGVPMQ MLPEIRSSAE VYGEITGGRL 250 260 270 280 290 300 GELLGGIPVA SALGDQQAAL FGQTCFSEGE TKSTYGTGTF MVMNTGDKLI NSYSGLLTTV 310 320 330 340 350 360 GYKIGDQDTV YALEGSIAVT GSLVQWMRDQ MGLISTAAEI ETLALTVEDN GGAYFVPAFS 370 380 390 400 410 420 GLFAPYWRSD ARGVIAGLTR YVTKAHLARA VLEATAWQTR EIADAMTKDS GVELTALKVD 430 440 450 460 470 480 GGMTSNNLLM QTLADFVDAP VVRPMVAETT CLGAAYAAGL AVGFWNSTDD LRANWRRAAE 490 500 510 WTPRMDADIR DREYKSWLKA VERTMGWLED EE

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939109 Genomic DNA. Translation: CAC36363.1.
RefSeq	NP_625935.1.
3D structure databases
HSSP	HSSP built from PDB template 1GLC based on UniProtKB P08859.
ModBase	Search...
Genome annotation databases
GeneID	1097091.
GenomeReviews	Gene locus SCO1660 in contig AL645882_GR.
KEGG	sco:SCO1660.
NMPDR	fig|100226.1.peg.1627.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ADA7.
OMA	LMERYEP.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO1660-MON.
BRENDA	2.7.1.30. 1084.
Family and domain databases
HAMAP	MF_00186. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK1_STRCO

Accession

Primary (citable) accession number: Q9ADA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)