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Q9ACU1

- CRIT_STRCO

UniProt

Q9ACU1 - CRIT_STRCO

Protein

Bifunctional protein CrtB/UppS

Gene

crtB/uppS3

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the reaction from prephytoene diphosphate to phytoene.By similarity
    Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

    Catalytic activityi

    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei329 – 3291By similarity
    Metal bindingi329 – 3291MagnesiumBy similarity
    Binding sitei334 – 3341SubstrateBy similarity
    Binding sitei346 – 3461SubstrateBy similarity
    Active sitei377 – 3771Proton acceptorBy similarity
    Binding sitei378 – 3781SubstrateBy similarity
    Binding sitei380 – 3801SubstrateBy similarity
    Binding sitei497 – 4971SubstrateBy similarity
    Metal bindingi515 – 5151MagnesiumBy similarity

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein CrtB/UppS
    Including the following 2 domains:
    Phytoene synthase (EC:2.5.1.32)
    Isoprenyl transferase (EC:2.5.1.-)
    Gene namesi
    Name:crtB/uppS3
    Ordered Locus Names:SCP1.212
    Encoded oniPlasmid SCP10 Publication
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Plasmid SCP1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Bifunctional protein CrtB/UppSPRO_0000123687Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCP1.212.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ACU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni330 – 3334Substrate bindingBy similarity
    Regioni374 – 3763Substrate bindingBy similarity
    Regioni502 – 5043Substrate bindingBy similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the phytoene/squalene synthase family.Curated
    In the C-terminal section; belongs to the UPP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0020.
    HOGENOMiHOG000105666.
    OMAiFAVELWA.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    PF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    SSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ACU1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRDWSACGS LLLVMTVAKD RGGPAVAGSG GGVESPELRA AYEVCEAEAR    50
    QFAVELWAAA ETLPVETRPS LYAIASWSAY TDRIIDEGPL EGREERLAQW 100
    SADTLADLRA GHSSHPLRRA LVDTVRRWGL AEALIEEHLD SARADCAAVP 150
    VFETFKDQRR YLRGCSGALA ELWVPLLEPR GPEAFRLMSV LGEACQVADL 200
    FEDLPDDLAA GRCYLPRQDL RGLGLDVDDL RRGEREEALN AFVDAQLAHW 250
    RGLLEETVLA PSTVGARYQI FVHTLLLGAQ MHFDEVTLLR SRVLTQGLES 300
    LVTGDGRMSR RAARPGPGPV PGHIAVIADG NRRWAEARGL LADQGHRAGI 350
    RAVLRLVNAA QRTGIRHVTV YMFSTENWYR SQGEVAALFG AFADWFARGA 400
    QTVHELGVRV RWSGRRDRLE ESLASSFELL ESMTANNDKL TLTICLDYGG 450
    REELAAAARA LAAEAVAGTI RPEQIGMAEV ARHLYVPEMP DVDLLVRTCE 500
    QRISNFLPWH LAYAELVFDP APWPDFDLAR LRDAVDSYAG RERRFGGDAE 550
    LPAQAGNLEP ARNG 564
    Length:564
    Mass (Da):62,105
    Last modified:June 1, 2001 - v1
    Checksum:i88B1A330C1CC46C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL589148 Genomic DNA. Translation: CAC36733.1.
    RefSeqiNP_639818.1. NC_003903.1.
    WP_011039510.1. NC_003903.1.

    Genome annotation databases

    EnsemblBacteriaiCAC36733; CAC36733; CAC36733.
    GeneIDi1095290.
    KEGGisco:SCP1.212.
    PATRICi23746018. VBIStrCoe124346_8152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL589148 Genomic DNA. Translation: CAC36733.1 .
    RefSeqi NP_639818.1. NC_003903.1.
    WP_011039510.1. NC_003903.1.

    3D structure databases

    ProteinModelPortali Q9ACU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCP1.212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC36733 ; CAC36733 ; CAC36733 .
    GeneIDi 1095290.
    KEGGi sco:SCP1.212.
    PATRICi 23746018. VBIStrCoe124346_8152.

    Phylogenomic databases

    eggNOGi COG0020.
    HOGENOMi HOG000105666.
    OMAi FAVELWA.
    OrthoDBi EOG68H89T.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiCRIT_STRCO
    AccessioniPrimary (citable) accession number: Q9ACU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3