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Q9ACU1

- CRIT_STRCO

UniProt

Q9ACU1 - CRIT_STRCO

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Protein

Bifunctional protein CrtB/UppS

Gene

crtB/uppS3

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reaction from prephytoene diphosphate to phytoene.By similarity
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

Catalytic activityi

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 3291By similarity
Metal bindingi329 – 3291MagnesiumBy similarity
Binding sitei334 – 3341SubstrateBy similarity
Binding sitei346 – 3461SubstrateBy similarity
Active sitei377 – 3771Proton acceptorBy similarity
Binding sitei378 – 3781SubstrateBy similarity
Binding sitei380 – 3801SubstrateBy similarity
Binding sitei497 – 4971SubstrateBy similarity
Metal bindingi515 – 5151MagnesiumBy similarity

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. cell wall organization Source: UniProtKB-KW
  5. peptidoglycan biosynthetic process Source: UniProtKB-KW
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein CrtB/UppS
Including the following 2 domains:
Phytoene synthase (EC:2.5.1.32)
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:crtB/uppS3
Ordered Locus Names:SCP1.212
Encoded oniPlasmid SCP10 Publication
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Plasmid SCP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Bifunctional protein CrtB/UppSPRO_0000123687Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi100226.SCP1.212.

Structurei

3D structure databases

ProteinModelPortaliQ9ACU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 3334Substrate bindingBy similarity
Regioni374 – 3763Substrate bindingBy similarity
Regioni502 – 5043Substrate bindingBy similarity

Sequence similaritiesi

In the N-terminal section; belongs to the phytoene/squalene synthase family.Curated
In the C-terminal section; belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000105666.
InParanoidiQ9ACU1.
OMAiFAVELWA.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
PF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
SSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ACU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRDWSACGS LLLVMTVAKD RGGPAVAGSG GGVESPELRA AYEVCEAEAR
60 70 80 90 100
QFAVELWAAA ETLPVETRPS LYAIASWSAY TDRIIDEGPL EGREERLAQW
110 120 130 140 150
SADTLADLRA GHSSHPLRRA LVDTVRRWGL AEALIEEHLD SARADCAAVP
160 170 180 190 200
VFETFKDQRR YLRGCSGALA ELWVPLLEPR GPEAFRLMSV LGEACQVADL
210 220 230 240 250
FEDLPDDLAA GRCYLPRQDL RGLGLDVDDL RRGEREEALN AFVDAQLAHW
260 270 280 290 300
RGLLEETVLA PSTVGARYQI FVHTLLLGAQ MHFDEVTLLR SRVLTQGLES
310 320 330 340 350
LVTGDGRMSR RAARPGPGPV PGHIAVIADG NRRWAEARGL LADQGHRAGI
360 370 380 390 400
RAVLRLVNAA QRTGIRHVTV YMFSTENWYR SQGEVAALFG AFADWFARGA
410 420 430 440 450
QTVHELGVRV RWSGRRDRLE ESLASSFELL ESMTANNDKL TLTICLDYGG
460 470 480 490 500
REELAAAARA LAAEAVAGTI RPEQIGMAEV ARHLYVPEMP DVDLLVRTCE
510 520 530 540 550
QRISNFLPWH LAYAELVFDP APWPDFDLAR LRDAVDSYAG RERRFGGDAE
560
LPAQAGNLEP ARNG
Length:564
Mass (Da):62,105
Last modified:June 1, 2001 - v1
Checksum:i88B1A330C1CC46C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589148 Genomic DNA. Translation: CAC36733.1.
RefSeqiNP_639818.1. NC_003903.1.
WP_011039510.1. NC_003903.1.

Genome annotation databases

EnsemblBacteriaiCAC36733; CAC36733; CAC36733.
GeneIDi1095290.
KEGGisco:SCP1.212.
PATRICi23746018. VBIStrCoe124346_8152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589148 Genomic DNA. Translation: CAC36733.1 .
RefSeqi NP_639818.1. NC_003903.1.
WP_011039510.1. NC_003903.1.

3D structure databases

ProteinModelPortali Q9ACU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCP1.212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC36733 ; CAC36733 ; CAC36733 .
GeneIDi 1095290.
KEGGi sco:SCP1.212.
PATRICi 23746018. VBIStrCoe124346_8152.

Phylogenomic databases

eggNOGi COG0020.
HOGENOMi HOG000105666.
InParanoidi Q9ACU1.
OMAi FAVELWA.
OrthoDBi EOG68H89T.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCRIT_STRCO
AccessioniPrimary (citable) accession number: Q9ACU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3