Q9ACJ8 (IF3_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-3

Gene names

Name:	infC
Ordered Locus Names:	TT_C0183

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins By similarity. HAMAP MF_00080
Subunit structure	Monomer By similarity. HAMAP MF_00080
Subcellular location	Cytoplasm By similarity HAMAP MF_00080.
Sequence similarities	Belongs to the IF-3 family.
Sequence caution	The sequence AAS80531.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Translation initiation factor IF-3 HAMAP MF_00080		PRO_0000177598

Sequences

	Sequence		Length	Mass (Da)
	Q9ACJ8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 55954FFC1E365E29	FASTA	171	19,866
	10 20 30 40 50 60 MKEYLTNERI RAKQVRVVGP DGKQLGIMDT REALRLAQEM DLDLVLVGPN ADPPVARIMD 70 80 90 100 110 120 YSKWRYEQQM AEKEARKKAK RTEVKSIKFR VKIDEHDYQT KLGHIKRFLQ EGHKVKVTIM 130 140 150 160 170 FRGREVAHPE LGERILNRVT EDLKDLAVVE MKPEMLGRDM NMLLAPVKVS A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3." Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F. EMBO J. 20:1829-1839(2001) [PubMed: 11296217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ409350 Genomic DNA. Translation: CAC35168.1. AE017221 Genomic DNA. Translation: AAS80531.1. Different initiation.
RefSeq	YP_004158.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q9ACJ8.
SMR	Q9ACJ8. Positions 2-77.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ACJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2774489.
GenomeReviews	Gene locus TT_C0183 in contig AE017221_GR.
PATRIC	23950759. VBITheThe54392_0184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0290.
HOGENOM	HBG744268.
OMA	APKAPIN.
PhylomeDB	Q9ACJ8.
ProtClustDB	PRK00028.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C0183-MONOMER.
Family and domain databases
HAMAP	MF_00080. IF-3. [Tree]
InterPro	IPR001288. Translation_initiation_fac_3. IPR019815. Translation_initiation_fac_3_C. IPR019814. Translation_initiation_fac_3_N. [Graphical view]
Gene3D	G3DSA:3.10.20.80. IF3. 1 hit. G3DSA:3.30.110.10. IF3. 1 hit.
PANTHER	PTHR10938. IF3. 1 hit.
Pfam	PF00707. IF3_C. 1 hit. PF05198. IF3_N. 1 hit. [Graphical view]
SUPFAM	SSF54364. IF3. 1 hit. SSF55200. IF3. 1 hit.
TIGRFAMs	TIGR00168. InfC. 1 hit.
PROSITE	PS00938. IF3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF3_THET2

Accession

Primary (citable) accession number: Q9ACJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program