ID   AROE_CAUCR              Reviewed;         285 AA.
AC   Q9AC57;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=CC_0003;
OS   Caulobacter crescentus (Caulobacter vibrioides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   MEDLINE=21173698; PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H.,
RA   Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J.,
RA   Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J.,
RA   Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L.,
RA   Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE005673; AAK21991.1; -; Genomic_DNA.
DR   PIR; C87249; C87249.
DR   RefSeq; NP_418823.1; -.
DR   HSSP; P43876; 1P77.
DR   GeneID; 944079; -.
DR   GenomeReviews; AE005673_GR; CC_0003.
DR   KEGG; ccr:CC_0003; -.
DR   NMPDR; fig|190650.1.peg.3; -.
DR   TIGR; CC_0003; -.
DR   HOGENOM; Q9AC57; -.
DR   OMA; Q9AC57; AYGFSAN.
DR   BRENDA; 1.1.1.25; 2191.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    285       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135998.
FT   NP_BIND     136    140       NADP (By similarity).
FT   ACT_SITE     73     73       Proton acceptor (Potential).
SQ   SEQUENCE   285 AA;  29015 MW;  91174F9C770C14FE CRC64;
     MTNAITGAAI VGGVCGQPIK HSMSPVIHNA WIAAAGLDAA YVPFAPAADR FETFVDGLRG
     GAVRGLNVTI PFKERALAVA DTASDLARMA GAANLLVFNE DGSVHADNTD GPGLLGAIAI
     QAPGFDVTAA PVVILGAGGA ARGAVAALLL AGAPRIAVVN RTVARAQDLA DTFGEKVVAK
     GEDALPALLP EAGLIINATS LGLGGGAGPS ADLTLTPKTA VVMDMVYKPL RTEFLRRAEA
     AGRRTVDGLE MLLRQAIPTF ETIYGQAPSP KIDVRVLALK LLGEV
//