Reviewed, UniProtKB/Swiss-Prot Q9AC57 (AROE_CAUCR)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	CC_0003

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000135998
Regions
	Nucleotide binding	136 – 140	5	NADP By similarity
Sites
	Active site	73	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9AC57-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 91174F9C770C14FE	FASTA	285	29,015
	10 20 30 40 50 60 MTNAITGAAI VGGVCGQPIK HSMSPVIHNA WIAAAGLDAA YVPFAPAADR FETFVDGLRG 70 80 90 100 110 120 GAVRGLNVTI PFKERALAVA DTASDLARMA GAANLLVFNE DGSVHADNTD GPGLLGAIAI 130 140 150 160 170 180 QAPGFDVTAA PVVILGAGGA ARGAVAALLL AGAPRIAVVN RTVARAQDLA DTFGEKVVAK 190 200 210 220 230 240 GEDALPALLP EAGLIINATS LGLGGGAGPS ADLTLTPKTA VVMDMVYKPL RTEFLRRAEA 250 260 270 280 AGRRTVDGLE MLLRQAIPTF ETIYGQAPSP KIDVRVLALK LLGEV

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK21991.1.
PIR	C87249.
RefSeq	NP_418823.1.
3D structure databases
HSSP	HSSP built from PDB template 1P77 based on UniProtKB P43876.
ModBase	Search...
Genome annotation databases
GeneID	944079.
GenomeReviews	Gene locus CC_0003 in contig AE005673_GR.
KEGG	ccr:CC_0003.
NMPDR	fig|190650.1.peg.3.
TIGR	CC_0003.
Phylogenomic databases
HOGENOM	Q9AC57.
OMA	Q9AC57. AYGFSAN.
Enzyme and pathway databases
BRENDA	1.1.1.25. 2191.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CAUCR

Accession

Primary (citable) accession number: Q9AC57

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)