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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi488MagnesiumUniRule annotation1
Metal bindingi494MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC0034-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CC_0034
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295771 – 712Polyribonucleotide nucleotidyltransferaseAdd BLAST712

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0034

Structurei

Secondary structure

1712
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi14 – 23Combined sources10
Beta strandi27 – 35Combined sources9
Beta strandi38 – 46Combined sources9
Beta strandi59 – 65Combined sources7
Helixi67 – 70Combined sources4
Beta strandi76 – 78Combined sources3
Helixi86 – 99Combined sources14
Helixi100 – 102Combined sources3
Beta strandi111 – 119Combined sources9
Beta strandi122 – 124Combined sources3
Helixi126 – 141Combined sources16
Beta strandi150 – 157Combined sources8
Beta strandi160 – 164Combined sources5
Helixi167 – 171Combined sources5
Beta strandi174 – 181Combined sources8
Beta strandi186 – 196Combined sources11
Helixi198 – 211Combined sources14
Helixi213 – 226Combined sources14
Helixi239 – 258Combined sources20
Helixi262 – 277Combined sources16
Turni278 – 281Combined sources4
Beta strandi292 – 294Combined sources3
Helixi295 – 312Combined sources18
Beta strandi313 – 316Combined sources4
Beta strandi329 – 333Combined sources5
Beta strandi339 – 347Combined sources9
Beta strandi350 – 359Combined sources10
Helixi361 – 363Combined sources3
Beta strandi364 – 369Combined sources6
Beta strandi372 – 376Combined sources5
Beta strandi378 – 383Combined sources6
Helixi386 – 389Combined sources4
Helixi400 – 413Combined sources14
Helixi414 – 416Combined sources3
Turni420 – 422Combined sources3
Beta strandi426 – 435Combined sources10
Helixi440 – 454Combined sources15
Beta strandi464 – 472Combined sources9
Beta strandi477 – 482Combined sources6
Helixi487 – 490Combined sources4
Beta strandi491 – 500Combined sources10
Beta strandi503 – 511Combined sources9
Helixi518 – 540Combined sources23
Beta strandi552 – 554Combined sources3
Beta strandi556 – 561Combined sources6
Helixi564 – 566Combined sources3
Helixi567 – 571Combined sources5
Helixi573 – 575Combined sources3
Helixi576 – 585Combined sources10
Beta strandi588 – 591Combined sources4
Beta strandi593 – 603Combined sources11
Helixi604 – 612Combined sources9
Beta strandi627 – 635Combined sources9
Beta strandi638 – 646Combined sources9
Beta strandi649 – 659Combined sources11
Turni662 – 664Combined sources3
Beta strandi673 – 680Combined sources8
Turni683 – 685Combined sources3
Beta strandi688 – 690Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AIDX-ray2.60A/B/C1-712[»]
4AIMX-ray3.30A1-712[»]
4AM3X-ray3.00A/B/C1-712[»]
ProteinModelPortaliQ9AC32
SMRiQ9AC32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 614KHUniRule annotationAdd BLAST60
Domaini624 – 692S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9AC32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIKRKTIE WGGKTLVLET GRIARQADGA VLATMGETVV LATAVFAKSQ
60 70 80 90 100
KPGQDFFPLT VNYQEKTFAA GKIPGGFFKR EGRPSEKETL VSRLIDRPIR
110 120 130 140 150
PLFVKGFKNE VQVVVTVLQH DLENDPDILG MVAASAALCL SGAPFMGPIG
160 170 180 190 200
AARVGWVDGA YVLNPTLDEM KESKMDLVVA GTADAVMMVE SEIQELSEEI
210 220 230 240 250
VLGGVNFAHQ QMQAVIDAII DLAEHAAKEP FAFEPEDTDA IKAKMKDLVG
260 270 280 290 300
ADIAAAYKIQ KKQDRYEAVG AAKKKAIAAL GLSDENPTGY DPLKLGAIFK
310 320 330 340 350
ELEADVVRRG ILDTGLRIDG RDVKTVRPIL GEVGILPRTH GSALFTRGET
360 370 380 390 400
QAIVVATLGT GDDEQFIDAL EGTYKESFLL HYNFPPYSVG ETGRMGSPGR
410 420 430 440 450
REIGHGKLAW RALRPMLPTK EDFPYTIRLV SEITESNGSS SMATVCGSSL
460 470 480 490 500
AMMDAGVPLV RPVSGIAMGL ILEQDGFAVL SDILGDEDHL GDMDFKVAGT
510 520 530 540 550
SEGLTSLQMD IKIAGITPAI MEQALAQAKE GRAHILGEMN KAMDAPRADV
560 570 580 590 600
GDFAPKIETI NIPTDKIREV IGSGGKVIRE IVATTGAKVD INDDGVVKVS
610 620 630 640 650
ASDGAKIKAA IDWIKSITDE AEVGKIYDGK VVKVVDFGAF VNFFGAKDGL
660 670 680 690 700
VHVSQISNER VAKPSDVLKE GQMVKVKLLG FDDRGKTKLS MKVVDQETGE
710
DLSKKEAAAE EA
Length:712
Mass (Da):76,448
Last modified:June 1, 2001 - v1
Checksum:i4772C4229037CA96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22022.1
PIRiB87253
RefSeqiNP_418854.1, NC_002696.2
WP_010917924.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22022; AAK22022; CC_0034
GeneIDi944094
KEGGiccr:CC_0034
PATRICifig|190650.5.peg.34

Similar proteinsi

Entry informationi

Entry nameiPNP_CAUVC
AccessioniPrimary (citable) accession number: Q9AC32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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