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Q9ABV2

- GLMS_CAUCR

UniProt

Q9ABV2 - GLMS_CAUCR

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei601 – 6011For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCAULO:CC0118-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CC_0118
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135315Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9ABV2.
SMRiQ9ABV2. Positions 2-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini280 – 421142SIS 1UniRule annotationAdd
BLAST
Domaini454 – 596143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ABV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGIVGK EPVADRLIES LKRLEYRGYD SAGVAGVVGG KVERRRAQGK
60 70 80 90 100
IKALEAVLAD EPLTATTGIG HTRWATHGAP NVRNAHPHTA GRVTLVHNGI
110 120 130 140 150
IENFAELKAE LAGMGRTFES DTDTEVIAQL IDVALAKGLA PLDAFKATLD
160 170 180 190 200
RLTGAYALAV LIQGEADLLL GARRGSPLVV GEGQGEMFLG SDALAVGPFT
210 220 230 240 250
NRVIYLEEGD YVALDHDSRR IFDASGARVE RPVRVVPTSS VMLEKGNYRH
260 270 280 290 300
FMEKEIHDQP EGCQRTIAAY VDTLTSKAAV PGDIDFATLD RIQIVACGTS
310 320 330 340 350
YIAGVIGKYL IEQLADLPVD VEIASEFRYR TPALRPGSLV VAMSQSGETA
360 370 380 390 400
DTLAALRYCK AKGMKSAVVV NAQESTMARE VDVVWPIHCG PEIGVASTKA
410 420 430 440 450
FTAQVSVMIA LAIAAAKARG TIDAAEEQRL VKVLLEAPRL IAEAIGLEDA
460 470 480 490 500
IKEIAADVAK ARDVLYLGRG PMSALALEGA LKLKEISYIH AEGYAAGELK
510 520 530 540 550
HGPIALVDDQ TPIVILAPYD SYFEKSASNM SEVMARGGQV IFITDTEGVK
560 570 580 590 600
HAPAGAKVVV TAPASDPLVS TLVMSAPIQL LAYHVAVVKG ADVDQPRNLA

KSVTVE
Length:606
Mass (Da):64,339
Last modified:January 23, 2007 - v3
Checksum:i70BD507E7F3A637E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22105.1.
PIRiE87263.
RefSeqiNP_418937.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22105; AAK22105; CC_0118.
GeneIDi944175.
KEGGiccr:CC_0118.
PATRICi21297152. VBICauCre124313_0115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22105.1 .
PIRi E87263.
RefSeqi NP_418937.1. NC_002696.2.

3D structure databases

ProteinModelPortali Q9ABV2.
SMRi Q9ABV2. Positions 2-606.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK22105 ; AAK22105 ; CC_0118 .
GeneIDi 944175.
KEGGi ccr:CC_0118.
PATRICi 21297152. VBICauCre124313_0115.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CAULO:CC0118-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiGLMS_CAUCR
AccessioniPrimary (citable) accession number: Q9ABV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3