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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei601For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciCAULO:CC0118-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CC_0118
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353152 – 606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST605

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_0118.

Structurei

3D structure databases

ProteinModelPortaliQ9ABV2.
SMRiQ9ABV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini280 – 421SIS 1UniRule annotationAdd BLAST142
Domaini454 – 596SIS 2UniRule annotationAdd BLAST143

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ABV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIIGIVGK EPVADRLIES LKRLEYRGYD SAGVAGVVGG KVERRRAQGK
60 70 80 90 100
IKALEAVLAD EPLTATTGIG HTRWATHGAP NVRNAHPHTA GRVTLVHNGI
110 120 130 140 150
IENFAELKAE LAGMGRTFES DTDTEVIAQL IDVALAKGLA PLDAFKATLD
160 170 180 190 200
RLTGAYALAV LIQGEADLLL GARRGSPLVV GEGQGEMFLG SDALAVGPFT
210 220 230 240 250
NRVIYLEEGD YVALDHDSRR IFDASGARVE RPVRVVPTSS VMLEKGNYRH
260 270 280 290 300
FMEKEIHDQP EGCQRTIAAY VDTLTSKAAV PGDIDFATLD RIQIVACGTS
310 320 330 340 350
YIAGVIGKYL IEQLADLPVD VEIASEFRYR TPALRPGSLV VAMSQSGETA
360 370 380 390 400
DTLAALRYCK AKGMKSAVVV NAQESTMARE VDVVWPIHCG PEIGVASTKA
410 420 430 440 450
FTAQVSVMIA LAIAAAKARG TIDAAEEQRL VKVLLEAPRL IAEAIGLEDA
460 470 480 490 500
IKEIAADVAK ARDVLYLGRG PMSALALEGA LKLKEISYIH AEGYAAGELK
510 520 530 540 550
HGPIALVDDQ TPIVILAPYD SYFEKSASNM SEVMARGGQV IFITDTEGVK
560 570 580 590 600
HAPAGAKVVV TAPASDPLVS TLVMSAPIQL LAYHVAVVKG ADVDQPRNLA

KSVTVE
Length:606
Mass (Da):64,339
Last modified:January 23, 2007 - v3
Checksum:i70BD507E7F3A637E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22105.1.
PIRiE87263.
RefSeqiNP_418937.1. NC_002696.2.
WP_010918007.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22105; AAK22105; CC_0118.
GeneIDi944175.
KEGGiccr:CC_0118.
PATRICifig|190650.5.peg.115.

Similar proteinsi

Entry informationi

Entry nameiGLMS_CAUCR
AccessioniPrimary (citable) accession number: Q9ABV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome