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Q9ABU1

- ASSY_CAUCR

UniProt

Q9ABU1 - ASSY_CAUCR

Protein

Argininosuccinate synthase

Gene

argG

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei92 – 921CitrullineUniRule annotation
    Binding sitei97 – 971CitrullineUniRule annotation
    Binding sitei122 – 1221ATP; via amide nitrogenUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei129 – 1291AspartateUniRule annotation
    Binding sitei132 – 1321CitrullineUniRule annotation
    Binding sitei183 – 1831CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei268 – 2681CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCAULO:CC0129-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:CC_0129
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Argininosuccinate synthasePRO_0000148582Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ABU1.
    SMRiQ9ABU1. Positions 6-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ABU1-1 [UniParc]FASTAAdd to Basket

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    MADKSVKKVV LAYSGGLDTS IILKWLQTEY GAEVITFTAD LGQGEEIEPA    50
    RAKALAAGVK PENIFIEDVR EEFVRDYVFP MFRANTVYEG QYLLGTSIAR 100
    PLIAKKQIEI ARKMGADAVS HGATGKGNDQ VRFELGYYGL EPDITVIAPW 150
    REWDFKSREA LLDFAEKHQI QITKDKRGEA PFSVDANLLH SSSEGKVLED 200
    PAVEAPEFVH MRTIAPEDAP DAPTIITIDF EKGDPVAIDG VAMSPATLLT 250
    KLNELGRDNG VGRLDLVENR FVGMKSRGVY ETPGGTILLA AHRGIESITL 300
    DRGAMHLKDE LMPKYASLVY NGFWFSPERE MLQAAIDYSQ DKVTGRVRVK 350
    LYKGNVTVIG RESPYSLYDQ DLVTFEEGKV AYDHRDAGGF IKLNALRLRV 400
    LAKRDKRG 408
    Length:408
    Mass (Da):45,331
    Last modified:June 1, 2001 - v1
    Checksum:i06571CBDC38B0FBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22116.1.
    PIRiH87264.
    RefSeqiNP_418948.1. NC_002696.2.
    WP_010918018.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK22116; AAK22116; CC_0129.
    GeneIDi944187.
    KEGGiccr:CC_0129.
    PATRICi21297174. VBICauCre124313_0126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22116.1 .
    PIRi H87264.
    RefSeqi NP_418948.1. NC_002696.2.
    WP_010918018.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali Q9ABU1.
    SMRi Q9ABU1. Positions 6-407.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK22116 ; AAK22116 ; CC_0129 .
    GeneIDi 944187.
    KEGGi ccr:CC_0129.
    PATRICi 21297174. VBICauCre124313_0126.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CAULO:CC0129-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiASSY_CAUCR
    AccessioniPrimary (citable) accession number: Q9ABU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3