Q9ABK5 (G6PI_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	CC_0222

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180617
Sites
	Active site	349	1	Proton donor By similarity
	Active site	380	1	By similarity
	Active site	508	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ABK5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B233DFBAF7FD1595	FASTA	539	57,526
	10 20 30 40 50 60 MADLDAAWTR LEAAAKAAGD KRIVEFFDAE PGRLDALTLD VAGLHLDLSK QAWDEAGLEA 70 80 90 100 110 120 ALDLAHAADV EGARARMFDG EAINSSEGRA VLHTALRAPA GADVKALGQP VMAEVDAVRQ 130 140 150 160 170 180 RMKAFAQAVR SGAIKGATGK PFKAILHIGI GGSDLGPRLL WDALRPVKPS IDLRFVANVD 190 200 210 220 230 240 GAEFALTTAD MDPEETLVMV VSKTFTTQET MANAGAARAW LVAALGEQGA NQHLAAISTA 250 260 270 280 290 300 LDKTAAFGVP DDRVFGFWDW VGGRYSLWSS VSLSVAVAAG WDAFQGFLDG GAAMDEHFRT 310 320 330 340 350 360 APLEQNAPVL VALAQIFNRN GLDRRARSVV PYSHRLRRLA AFLQQLEMES NGKSVGPDGQ 370 380 390 400 410 420 PAKRGTATVV FGDEGTNVQH AYFQCMHQGT DITPMELIGV AKSDEGPAGM HEKLLSNLLA 430 440 450 460 470 480 QAEAFMVGRT TDDVVAELTA KGVSDAEIAT LAPQRTFAGN RPSTLVLLDR LTPQTFGALI 490 500 510 520 530 ALYEHKTFVE GVIWGINSFD QWGVELGKVM ANRILPELES GASGQHDPST AGLIQRLKR

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK22209.1.
PIR	E87276.
RefSeq	NP_419041.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q9ABK5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	944285.
GenomeReviews	Gene locus CC_0222 in contig AE005673_GR.
KEGG	ccr:CC_0222.
NMPDR	fig|190650.1.peg.221.
PATRIC	21297360. VBICauCre124313_0218.
TIGR	CC_0222.
Phylogenomic databases
HOGENOM	HBG352954.
OMA	DGPRLHY.
ProtClustDB	PRK00179.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CAUCR

Accession

Primary (citable) accession number: Q9ABK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program