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Q9ABG6 (PANE_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:CC_0261
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Putative 2-dehydropantoate 2-reductase
PRO_0000157312

Regions

Nucleotide binding8 – 136NADP By similarity

Sites

Active site1751Proton donor By similarity
Binding site981NADP; via amide nitrogen By similarity
Binding site981Substrate By similarity
Binding site1791Substrate By similarity
Binding site2441Substrate By similarity
Binding site2561NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ABG6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F4E50CC43D2EB746

FASTA29030,189
        10         20         30         40         50         60 
MTSIAVIGPG AVGGTLAAWL AQKPDHVVTV CVRTPFEALA VETPEGAISA TPRVATSPES 

        70         80         90        100        110        120 
LAPVDWVLVT TKTYDTDATW TWLDALVGPQ TRVAILRNGV EHVAPFVGKI AAERLVPAVV 

       130        140        150        160        170        180 
DIPAERSAPG RMLQRRNGWI KVPVGPAGEA FAALFAHTPI ELHVVEDFVT EAWKKLALNC 

       190        200        210        220        230        240 
AGAVNALVLK PAGIAHDEGA AQVMRSLVRE CVAVGRAEGA DLSDDLPDQV IAGYRAADPG 

       250        260        270        280        290 
SVNSLHADRA AGRAMELDAR NGVIVRRGAA HGIATPANAM VVALLNAAAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK22248.1.
PIRD87281.
RefSeqNP_419080.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9ABG6.
SMRQ9ABG6. Positions 4-285.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK22248; AAK22248; CC_0261.
GeneID942395.
KEGGccr:CC_0261.
PATRIC21297436. VBICauCre124313_0256.

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050226.
KOK00077.
OMARAPEDMG.
OrthoDBEOG6V7BJJ.
ProtClustDBPRK06522.

Enzyme and pathway databases

BioCycCAULO:CC0261-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_CAUCR
AccessionPrimary (citable) accession number: Q9ABG6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: December 11, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways