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Q9ABG6

- PANE_CAUCR

UniProt

Q9ABG6 - PANE_CAUCR

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Protein

Putative 2-dehydropantoate 2-reductase

Gene
CC_0261
Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADP; via amide nitrogen By similarity
Binding sitei98 – 981Substrate By similarity
Active sitei175 – 1751Proton donor By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei256 – 2561NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCAULO:CC0261-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:CC_0261
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Putative 2-dehydropantoate 2-reductasePRO_0000157312Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9ABG6.
SMRiQ9ABG6. Positions 2-289.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050226.
KOiK00077.
OMAiGGTKFQV.
OrthoDBiEOG6V7BJJ.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ABG6-1 [UniParc]FASTAAdd to Basket

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MTSIAVIGPG AVGGTLAAWL AQKPDHVVTV CVRTPFEALA VETPEGAISA    50
TPRVATSPES LAPVDWVLVT TKTYDTDATW TWLDALVGPQ TRVAILRNGV 100
EHVAPFVGKI AAERLVPAVV DIPAERSAPG RMLQRRNGWI KVPVGPAGEA 150
FAALFAHTPI ELHVVEDFVT EAWKKLALNC AGAVNALVLK PAGIAHDEGA 200
AQVMRSLVRE CVAVGRAEGA DLSDDLPDQV IAGYRAADPG SVNSLHADRA 250
AGRAMELDAR NGVIVRRGAA HGIATPANAM VVALLNAAAL 290
Length:290
Mass (Da):30,189
Last modified:June 1, 2001 - v1
Checksum:iF4E50CC43D2EB746
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK22248.1.
PIRiD87281.
RefSeqiNP_419080.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22248; AAK22248; CC_0261.
GeneIDi942395.
KEGGiccr:CC_0261.
PATRICi21297436. VBICauCre124313_0256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK22248.1 .
PIRi D87281.
RefSeqi NP_419080.1. NC_002696.2.

3D structure databases

ProteinModelPortali Q9ABG6.
SMRi Q9ABG6. Positions 2-289.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK22248 ; AAK22248 ; CC_0261 .
GeneIDi 942395.
KEGGi ccr:CC_0261.
PATRICi 21297436. VBICauCre124313_0256.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050226.
KOi K00077.
OMAi GGTKFQV.
OrthoDBi EOG6V7BJJ.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci CAULO:CC0261-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiPANE_CAUCR
AccessioniPrimary (citable) accession number: Q9ABG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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