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Protein

Putative 2-dehydropantoate 2-reductase

Gene

CC_0261

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (CC_0261)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98NADP; via amide nitrogenBy similarity1
Binding sitei98SubstrateBy similarity1
Active sitei175Proton donorBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei244SubstrateBy similarity1
Binding sitei256NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciCAULO:CC0261-MONOMER
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:CC_0261
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573121 – 290Putative 2-dehydropantoate 2-reductaseAdd BLAST290

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0261

Structurei

3D structure databases

ProteinModelPortaliQ9ABG6
SMRiQ9ABG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG4108NKJ Bacteria
COG1893 LUCA
HOGENOMiHOG000050226
KOiK00077
OMAiVGCYFGA

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ABG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIAVIGPG AVGGTLAAWL AQKPDHVVTV CVRTPFEALA VETPEGAISA
60 70 80 90 100
TPRVATSPES LAPVDWVLVT TKTYDTDATW TWLDALVGPQ TRVAILRNGV
110 120 130 140 150
EHVAPFVGKI AAERLVPAVV DIPAERSAPG RMLQRRNGWI KVPVGPAGEA
160 170 180 190 200
FAALFAHTPI ELHVVEDFVT EAWKKLALNC AGAVNALVLK PAGIAHDEGA
210 220 230 240 250
AQVMRSLVRE CVAVGRAEGA DLSDDLPDQV IAGYRAADPG SVNSLHADRA
260 270 280 290
AGRAMELDAR NGVIVRRGAA HGIATPANAM VVALLNAAAL
Length:290
Mass (Da):30,189
Last modified:June 1, 2001 - v1
Checksum:iF4E50CC43D2EB746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22248.1
PIRiD87281
RefSeqiNP_419080.1, NC_002696.2
WP_010918150.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22248; AAK22248; CC_0261
GeneIDi942395
KEGGiccr:CC_0261
PATRICifig|190650.5.peg.256

Similar proteinsi

Entry informationi

Entry nameiPANE_CAUVC
AccessioniPrimary (citable) accession number: Q9ABG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health