Reviewed, UniProtKB/Swiss-Prot Q9ABG6 (PANE_CAUCR)

Names and origin

Protein names

Recommended name:
    Putative 2-dehydropantoate 2-reductase
    EC=1.1.1.169
Alternative name(s):
    Ketopantoate reductase
      Short name=KPA reductase
      Short name=KPR

Gene names

Ordered Locus Names:

CC_0261

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.
Catalytic activity	(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the ketopantoate reductase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-dehydropantoate 2-reductase activity Inferred from electronic annotation. Source: EC NADP or NADPH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Putative 2-dehydropantoate 2-reductase		PRO_0000157312
Regions
	Nucleotide binding	8 – 13	6	NADP By similarity
Sites
	Active site	175	1	Proton donor By similarity
	Binding site	98	1	NADP; via amide nitrogen By similarity
	Binding site	98	1	Substrate By similarity
	Binding site	179	1	Substrate By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	256	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ABG6-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F4E50CC43D2EB746	FASTA	290	30,189
	10 20 30 40 50 60 MTSIAVIGPG AVGGTLAAWL AQKPDHVVTV CVRTPFEALA VETPEGAISA TPRVATSPES 70 80 90 100 110 120 LAPVDWVLVT TKTYDTDATW TWLDALVGPQ TRVAILRNGV EHVAPFVGKI AAERLVPAVV 130 140 150 160 170 180 DIPAERSAPG RMLQRRNGWI KVPVGPAGEA FAALFAHTPI ELHVVEDFVT EAWKKLALNC 190 200 210 220 230 240 AGAVNALVLK PAGIAHDEGA AQVMRSLVRE CVAVGRAEGA DLSDDLPDQV IAGYRAADPG 250 260 270 280 290 SVNSLHADRA AGRAMELDAR NGVIVRRGAA HGIATPANAM VVALLNAAAL

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK22248.1.
PIR	D87281.
RefSeq	NP_419080.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	942395.
GenomeReviews	Gene locus CC_0261 in contig AE005673_GR.
KEGG	ccr:CC_0261.
NMPDR	fig|190650.1.peg.260.
TIGR	CC_0261.
Phylogenomic databases
HOGENOM	Q9ABG6.
OMA	DASVWLR.
Enzyme and pathway databases
BRENDA	1.1.1.169. 2191.
Family and domain databases
InterPro	IPR003710. ApbA. IPR013752. ApbA_C. IPR013332. ApbA_N. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR21708:SF21. ApbA. 1 hit.
Pfam	PF02558. ApbA. 1 hit. PF08546. ApbA_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00745. apbA_panE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANE_CAUCR

Accession

Primary (citable) accession number: Q9ABG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)