Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ABG6

- PANE_CAUCR

UniProt

Q9ABG6 - PANE_CAUCR

Protein

Putative 2-dehydropantoate 2-reductase

Gene

CC_0261

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981NADP; via amide nitrogenBy similarity
    Binding sitei98 – 981SubstrateBy similarity
    Active sitei175 – 1751Proton donorBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Binding sitei256 – 2561NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCAULO:CC0261-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:CC_0261
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Putative 2-dehydropantoate 2-reductasePRO_0000157312Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ABG6.
    SMRiQ9ABG6. Positions 2-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050226.
    KOiK00077.
    OMAiGGTKFQV.
    OrthoDBiEOG6V7BJJ.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ABG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSIAVIGPG AVGGTLAAWL AQKPDHVVTV CVRTPFEALA VETPEGAISA    50
    TPRVATSPES LAPVDWVLVT TKTYDTDATW TWLDALVGPQ TRVAILRNGV 100
    EHVAPFVGKI AAERLVPAVV DIPAERSAPG RMLQRRNGWI KVPVGPAGEA 150
    FAALFAHTPI ELHVVEDFVT EAWKKLALNC AGAVNALVLK PAGIAHDEGA 200
    AQVMRSLVRE CVAVGRAEGA DLSDDLPDQV IAGYRAADPG SVNSLHADRA 250
    AGRAMELDAR NGVIVRRGAA HGIATPANAM VVALLNAAAL 290
    Length:290
    Mass (Da):30,189
    Last modified:June 1, 2001 - v1
    Checksum:iF4E50CC43D2EB746
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22248.1.
    PIRiD87281.
    RefSeqiNP_419080.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK22248; AAK22248; CC_0261.
    GeneIDi942395.
    KEGGiccr:CC_0261.
    PATRICi21297436. VBICauCre124313_0256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK22248.1 .
    PIRi D87281.
    RefSeqi NP_419080.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali Q9ABG6.
    SMRi Q9ABG6. Positions 2-289.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK22248 ; AAK22248 ; CC_0261 .
    GeneIDi 942395.
    KEGGi ccr:CC_0261.
    PATRICi 21297436. VBICauCre124313_0256.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050226.
    KOi K00077.
    OMAi GGTKFQV.
    OrthoDBi EOG6V7BJJ.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci CAULO:CC0261-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiPANE_CAUCR
    AccessioniPrimary (citable) accession number: Q9ABG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3