Q9ABF2 (GLSA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaminase
EC=3.5.1.2

Gene names

Name:	glsA
Ordered Locus Names:	CC_0276

Organism

Caulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]

Taxonomic identifier

190650 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter crescentus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00313
Sequence similarities	Belongs to the glutaminase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glutaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Glutaminase HAMAP-Rule MF_00313		PRO_0000110600
Sites
	Binding site	66	1	Substrate By similarity
	Binding site	116	1	Substrate By similarity
	Binding site	159	1	Substrate By similarity
	Binding site	166	1	Substrate By similarity
	Binding site	190	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	260	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ABF2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5B550D1025EC40DF	FASTA	306	32,286
	10 20 30 40 50 60 MKALSIPDVL AEVAVLVRPH FGKGKPADYI PQLATVPGGK FGMAVRMVDG DEHVIGDADE 70 80 90 100 110 120 GFSVQSITKV FALGLALNRL GDEIWTRVGK EPSGTPFNHL SLLEAEQGVP RNPFINAGAL 130 140 150 160 170 180 AVTDVLMDVT RDPAALVRDF GGFLCGERLE IDPAVATSEL AHAWQNRAIA SLMRAKGTIT 190 200 210 220 230 240 HDPEAVVAAY CRQCALSMSC RQLARAFLPL AAGGFSPIAQ ETVFPERLTR RLNALLLTCG 250 260 270 280 290 300 IYDSVGSFAY RVGLPAKSGV GGGIVAVVPG KATVAVWSPE LDRFGTSVVG TAALEAFSQI TNCSVL

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK22263.1.
PIR	C87283.
RefSeq	NP_419095.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q9ABF2.
SMR	Q9ABF2. Positions 24-290.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK22263; AAK22263; CC_0276.
GeneID	942381.
KEGG	ccr:CC_0276.
PATRIC	21297472. VBICauCre124313_0274.
Phylogenomic databases
eggNOG	COG2066.
HOGENOM	HOG000216890.
KO	K01425.
OMA	EPSGNPF.
ProtClustDB	PRK00971.
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
HAMAP	MF_00313. Glutaminase.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR015868. Glutaminase. [Graphical view]
PANTHER	PTHR12544. PTHR12544. 1 hit.
Pfam	PF04960. Glutaminase. 1 hit. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
TIGRFAMs	TIGR03814. Gln_ase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLSA_CAUCR

Accession

Primary (citable) accession number: Q9ABF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program