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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCAULO:CC0279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CC_0279
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829411 – 308Methionyl-tRNA formyltransferaseAdd BLAST308

Proteomic databases

PRIDEiQ9ABE9.

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0279.

Structurei

3D structure databases

ProteinModelPortaliQ9ABE9.
SMRiQ9ABE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ABE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAFLGTPD FAVTCLAELV ASGHEIVCVY SQPPAPRGRG QDLKPSPVHA
60 70 80 90 100
FAEGLGLPVR TPVSMKTPEE IAAFQALDLD AAVVVAFGQI LVKDVLEAPK
110 120 130 140 150
HGCFNLHASL LPRWRGAAPI QRAIMAGDAV TGVQVMRMSE GLDEGPILMS
160 170 180 190 200
QQVAIADDDT AASLHDKLAA VGARLLPVAL AAIEREVVQE TPQAEDGVTY
210 220 230 240 250
AKKIKSAEAR IDWTRPAAEI DRHIRGLSPF PGAWFEAPSE KGPVRVKALL
260 270 280 290 300
SRVEAASGVA GTTLDDALLI ACGEGSIRLL KAQREGKGVQ DAQTFTRGFP

IATGTVLA
Length:308
Mass (Da):32,531
Last modified:June 1, 2001 - v1
Checksum:iE3818F37280D7FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22266.1.
PIRiF87283.
RefSeqiNP_419098.1. NC_002696.2.
WP_010918168.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22266; AAK22266; CC_0279.
GeneIDi942377.
KEGGiccr:CC_0279.
PATRICifig|190650.5.peg.277.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFMT_CAUCR
AccessioniPrimary (citable) accession number: Q9ABE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families