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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCAULO:CC0279-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CC_0279
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829411 – 308Methionyl-tRNA formyltransferaseAdd BLAST308

Proteomic databases

PRIDEiQ9ABE9

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0279

Structurei

3D structure databases

ProteinModelPortaliQ9ABE9
SMRiQ9ABE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ABE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAFLGTPD FAVTCLAELV ASGHEIVCVY SQPPAPRGRG QDLKPSPVHA
60 70 80 90 100
FAEGLGLPVR TPVSMKTPEE IAAFQALDLD AAVVVAFGQI LVKDVLEAPK
110 120 130 140 150
HGCFNLHASL LPRWRGAAPI QRAIMAGDAV TGVQVMRMSE GLDEGPILMS
160 170 180 190 200
QQVAIADDDT AASLHDKLAA VGARLLPVAL AAIEREVVQE TPQAEDGVTY
210 220 230 240 250
AKKIKSAEAR IDWTRPAAEI DRHIRGLSPF PGAWFEAPSE KGPVRVKALL
260 270 280 290 300
SRVEAASGVA GTTLDDALLI ACGEGSIRLL KAQREGKGVQ DAQTFTRGFP

IATGTVLA
Length:308
Mass (Da):32,531
Last modified:June 1, 2001 - v1
Checksum:iE3818F37280D7FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22266.1
PIRiF87283
RefSeqiNP_419098.1, NC_002696.2
WP_010918168.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22266; AAK22266; CC_0279
GeneIDi942377
KEGGiccr:CC_0279
PATRICifig|190650.5.peg.277

Similar proteinsi

Entry informationi

Entry nameiFMT_CAUVC
AccessioniPrimary (citable) accession number: Q9ABE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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