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Q9ABD2 (PUR2_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:CC_0297
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151441

Regions

Domain110 – 315206ATP-grasp
Nucleotide binding136 – 19661ATP By similarity

Sites

Metal binding2851Magnesium or manganese By similarity
Metal binding2871Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ABD2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 426ABF4E04E3378C

FASTA42744,265
        10         20         30         40         50         60 
MEKLTILLVG SGGREHALAW KIAQSPLCGR LVAAPGNPGI EAVAELRAVK ATDADGLVAL 

        70         80         90        100        110        120 
AQEIGADLVV VGPESALEVG LADKLAAVGI PCFGGSQRAA QLETSKAFTK DFCQRHGLPT 

       130        140        150        160        170        180 
AAYGVFEDAA SAGAFLDTLE APFVIKADGL AAGKGVVIAP DRAAADAAVV DMLGGRFGSA 

       190        200        210        220        230        240 
GARVVIEEFM HGEEASLFAV CDGKTAVLFG AAQDHKRAYD GDEGPNTGGM GTYSPPPVLT 

       250        260        270        280        290        300 
DALIDQAWRE LIVPTVEGMA AEGNPYVGVL YAGLMLTPTG PKLVEYNARF GDPECQTLML 

       310        320        330        340        350        360 
RLDSDIVPIL LAAAKGELAN AEPPKWREEA AICVVLAAEG YPDAPKTGGR IQGADADFGD 

       370        380        390        400        410        420 
DVVVFHAGTT REFEGRLVAS GGRVLNVCAL GATLSEAREA AYGALETISL EGGFYRTDIG 


WRALQQR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK22284.1.
PIRH87285.
RefSeqNP_419116.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9ABD2.
SMRQ9ABD2. Positions 4-426.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK22284; AAK22284; CC_0297.
GeneID942342.
KEGGccr:CC_0297.
PATRIC21297514. VBICauCre124313_0295.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033464.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycCAULO:CC0297-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_CAUCR
AccessionPrimary (citable) accession number: Q9ABD2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways