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Protein

Glutamate 5-kinase

Gene

proB

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18ATPUniRule annotation1
Binding sitei59SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei158Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 179ATPUniRule annotation2
Nucleotide bindingi222 – 228ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAULO:CC0314-MONOMER
UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:CC_0314
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001096571 – 377Glutamate 5-kinaseAdd BLAST377

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0314

Structurei

3D structure databases

ProteinModelPortaliQ9ABB6
SMRiQ9ABB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 363PUAUniRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
HOGENOMiHOG000246368
KOiK00931
OMAiTHEIRFG

Family and domain databases

Gene3Di2.30.130.10, 1 hit
3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ABB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGSQGAFE AARRIVFKVG SALLVDAETG AANRAWLEAF CADAADLRAA
60 70 80 90 100
GKQVLVVSSG AVALGRRRLG LTGRKTTLPE KQAAAAAGQS LLMRAWEEAF
110 120 130 140 150
EPHGIGVAQI LLTRDDTEMR RRWLNARATT ETLMGLGVVP VVNENDTVVT
160 170 180 190 200
EEIRYGDNDR LAARVAQMAG ADLLVLLSDI DGLYTADPRK NPKAQHIPRV
210 220 230 240 250
SEITPEIAGM AEGANAAAGV GTGGMATKIA AARIARAAGC ATLITLGSRP
260 270 280 290 300
RPLAAIAAGE KATLIEAGAS PAAAYKAWIA GSLAPQGWVT VDAGAASALL
310 320 330 340 350
AGKSLLPAGV RAVEGPFDKG DAVRVRDENG REVARGLVRY DSADAQRIAG
360 370
LRSDAIEAEL GFTEGPMIHA DDLAVAH
Length:377
Mass (Da):39,041
Last modified:June 1, 2001 - v1
Checksum:iBB7541032E5EC5A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22301.1
PIRiA87288
RefSeqiNP_419133.1, NC_002696.2
WP_010918203.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22301; AAK22301; CC_0314
GeneIDi941095
KEGGiccr:CC_0314
PATRICifig|190650.5.peg.313

Similar proteinsi

Entry informationi

Entry nameiPROB_CAUVC
AccessioniPrimary (citable) accession number: Q9ABB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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