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Q9AAY3 (GCH1_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CC_0459
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119395

Sites

Metal binding1031Zinc By similarity
Metal binding1061Zinc By similarity
Metal binding1741Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9AAY3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3A01FB23DD8935BD

FASTA21223,781
        10         20         30         40         50         60 
MDALTRERTL IGSDDTTGLD LEPVQRPSKD EAMAAVRTLL AWAGDNPERE GLIDTPKRVV 

        70         80         90        100        110        120 
EAFDEWFAGY HGDPAKELSR TFEDVQGYDD MVMLRGIDVQ SHCEHHMAPF LGKAWIAYMP 

       130        140        150        160        170        180 
TGKVVGLSKL ARLVEIFAKR LQTQETMTMQ IADAIEDHLS AAGVAVLIDA EHQCMSTRGV 

       190        200        210 
HHHDVSTITT QFRGVFKTDK VLQQRFMDLV KK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK22446.1.
PIRB87306.
RefSeqNP_419278.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9AAY3.
SMRQ9AAY3. Positions 34-211.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK22446; AAK22446; CC_0459.
GeneID941959.
KEGGccr:CC_0459.
PATRIC21297856. VBICauCre124313_0465.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAKRTYDEE.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycCAULO:CC0459-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CAUCR
AccessionPrimary (citable) accession number: Q9AAY3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways