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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCAULO:CC0484-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:CC_0484
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Peptidyl-tRNA hydrolasePRO_0000187715Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9AAV9.
SMRiQ9AAV9. Positions 3-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0193.
HOGENOMiHOG000004796.
KOiK01056.
OMAiTTFMNRS.
OrthoDBiEOG6C5RTR.

Family and domain databases

Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AAV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLILAGLGNP EPKYEKNRHN VGFMAVDALA RKWGTAPWRA RFQGLACEGQ
60 70 80 90 100
VSTPDGPVKL LLLKPKTYYN ESGRAVGEAM KFFKLQPTDV IVFHDEIDMA
110 120 130 140 150
PGRFRMKSGG GAAGNNGIRS VTSQVGDAFR RGRIGVGHPG HKDAVMHYVL
160 170 180 190 200
GDFHKVEHQW LDPILDAIAD ALPFAAVGDD ERYQAEVMRL APAPKADPRK

PAKDD
Length:205
Mass (Da):22,472
Last modified:June 1, 2001 - v1
Checksum:iF64F92A527D6B8F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22471.1.
PIRiC87309.
RefSeqiNP_419303.1. NC_002696.2.
WP_010918372.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22471; AAK22471; CC_0484.
GeneIDi941902.
KEGGiccr:CC_0484.
PATRICi21297908. VBICauCre124313_0491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22471.1.
PIRiC87309.
RefSeqiNP_419303.1. NC_002696.2.
WP_010918372.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9AAV9.
SMRiQ9AAV9. Positions 3-166.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22471; AAK22471; CC_0484.
GeneIDi941902.
KEGGiccr:CC_0484.
PATRICi21297908. VBICauCre124313_0491.

Phylogenomic databases

eggNOGiCOG0193.
HOGENOMiHOG000004796.
KOiK01056.
OMAiTTFMNRS.
OrthoDBiEOG6C5RTR.

Enzyme and pathway databases

BioCyciCAULO:CC0484-MONOMER.

Family and domain databases

Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiPTH_CAUCR
AccessioniPrimary (citable) accession number: Q9AAV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.