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Q9AAU2 (RPOB_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:CC_0502
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length1356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13561356DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000047877

Sequences

Sequence LengthMass (Da)Tools
Q9AAU2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: BA113BA0EB7F6B51

FASTA1,356150,890
        10         20         30         40         50         60 
MAQSFTGKKR IRKSFGRIPE AVQMPNLIEV QRSSYEQFLQ RETRPGLRRD EGVEAVFKSV 

        70         80         90        100        110        120 
FPIKDFNERA VLEYVSYEFE EPKYDVEECI QRDMTFAAPL KVKLRLIVFE TEEETGARSV 

       130        140        150        160        170        180 
KDIKEQDVYM GDIPLMTDKG TFIVNGTERV IVSQMHRSPG VFFDHDKGKT HASGKLLFAA 

       190        200        210        220        230        240 
RVIPYRGSWL DFEFDAKDIV YVRIDRRRKL PATTFLYALG MDGEEILTTF YDVVPFEKRS 

       250        260        270        280        290        300 
GGWATPYKPE RWRGVKPEFP LVDADTGEEV APAGTKITAR QAKKFADGGL KTLLLAPEAL 

       310        320        330        340        350        360 
TGRYLARDAV NMATGEIYAE AGDELDVTSI QALADQGFST IDVLDIDHVT VGAYMRNTLR 

       370        380        390        400        410        420 
VDKNAIREDA LFDIYRVMRP GEPPTVEAAE AMFKSLFFDA ERYDLSSVGR VKMNMRLEQD 

       430        440        450        460        470        480 
VSDEVRILRK EDVLAVLKVL VGLRDGRGEI DDIDNLGNRR VRSVGELLEN QYRVGLLRME 

       490        500        510        520        530        540 
RAIKERMSSV DIDTVMPHDL INAKPAAAAV REFFGSSQLS QFMDQTNPLS EITHKRRLSA 

       550        560        570        580        590        600 
LGPGGLTRER AGFEVRDVHP THYGRICPIE TPEGPNIGLI NSLATHARVN KYGFIESPYR 

       610        620        630        640        650        660 
RVKDGKPQDE VVYMSAMEES KHVIAQSNIK VAEGEIVEDL VPGRINGEPT LLQKETVDLM 

       670        680        690        700        710        720 
DVSPRQVVSV AAALIPFLEN DDANRALMGS NMQRQAVPLV QSDAPLVGTG MEAVVARDSG 

       730        740        750        760        770        780 
AVVIAKRTGV VEQIDGTRIV IRATEETDPA RSGVDIYRMS KFQRSNQSTC INQRPLVKVG 

       790        800        810        820        830        840 
DRIVAGDIIA DGPSTELGEL ALGRNALVAF MPWNGYNFED SILISERIVR DDVFTSIHIE 

       850        860        870        880        890        900 
EFEVMARDTK LGPEEITRDI PNVGEEALRN LDEAGIVAIG AEVQPGDILV GKVTPKGESP 

       910        920        930        940        950        960 
MTPEEKLLRA IFGEKASDVR DTSLRLPPGV AGTIVDVRVF NRHGVDKDER ALAIERAEID 

       970        980        990       1000       1010       1020 
RLGKDRDDEF AILNRNISGR LKELLIGKVA LSGPKGLSRG EITAEGLAQV ASGLWWQIAL 

      1030       1040       1050       1060       1070       1080 
EDEKAMGELE SLRRLFDENR KRLDRRFEDK VDKLQRGDEL PPGVMKMVKV FVAVKRKLQP 

      1090       1100       1110       1120       1130       1140 
GDKMAGRHGN KGVISRILPI EDMPFLADGT HVDVVLNPLG VPSRMNVGQI FETHLGWACA 

      1150       1160       1170       1180       1190       1200 
NLGKQITNLL EDWQQGGQKQ ALVERLTEIY GPDEELPDTE EGLVELARNL GKGVPIATPV 

      1210       1220       1230       1240       1250       1260 
FDGARMDDIE GHLEMAGVNK SGQSILFDGL TGEQFKRPVT VGYIYMLKLH HLVDDKIHAR 

      1270       1280       1290       1300       1310       1320 
SIGPYSLVTQ QPLGGKAQFG GQRFGEMEVW ALEAYGAAYT LQEMLTVKSD DVAGRTKVYE 

      1330       1340       1350 
SIVRGDDTFE AGIPESFNVL VKEMRSLGLN VELENS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK22489.1.
PIRE87311.
RefSeqNP_419321.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9AAU2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID941861.
GenomeReviewsGene locus CC_0502 in contig AE005673_GR.
KEGGccr:CC_0502.
NMPDRfig|190650.1.peg.501.
PATRIC21297950. VBICauCre124313_0512.
TIGRCC_0502.

Phylogenomic databases

HOGENOMHBG285547.
OMAIGRNKTY.
ProtClustDBPRK00405.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 2 hits.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_CAUCR
AccessionPrimary (citable) accession number: Q9AAU2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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