ID   HEM6_CAUCR              Reviewed;         290 AA.
AC   Q9AAT8;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Coproporphyrinogen-III oxidase, aerobic;
DE            Short=Coproporphyrinogenase;
DE            Short=Coprogen oxidase;
DE            EC=1.3.3.3;
GN   Name=hemF; OrderedLocusNames=CC_0506;
OS   Caulobacter crescentus (Caulobacter vibrioides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   MEDLINE=21173698; PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H.,
RA   Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J.,
RA   Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J.,
RA   Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L.,
RA   Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- CATALYTIC ACTIVITY: Coproporphyrinogen-III + O(2) + 2 H(+) =
CC       protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
CC   -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC       protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step
CC       1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aerobic coproporphyrinogen-III oxidase
CC       family.
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DR   EMBL; AE005673; AAK22493.1; -; Genomic_DNA.
DR   PIR; A87312; A87312.
DR   RefSeq; NP_419325.1; -.
DR   GeneID; 941864; -.
DR   GenomeReviews; AE005673_GR; CC_0506.
DR   KEGG; ccr:CC_0506; -.
DR   NMPDR; fig|190650.1.peg.505; -.
DR   TIGR; CC_0506; -.
DR   HOGENOM; Q9AAT8; -.
DR   OMA; Q9AAT8; VKAYLLD.
DR   BRENDA; 1.3.3.3; 2191.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004109; F:coproporphyrinogen oxidase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006779; P:porphyrin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00333; -; 1.
DR   InterPro; IPR001260; Coprogen_oxidas.
DR   InterPro; IPR018375; Coproporphyrinogen-3_ox_CS.
DR   Gene3D; G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
DR   PANTHER; PTHR10755; Coprogen_oxidas; 1.
DR   Pfam; PF01218; Coprogen_oxidas; 1.
DR   PIRSF; PIRSF000166; Coproporphyri_ox; 1.
DR   PRINTS; PR00073; COPRGNOXDASE.
DR   PROSITE; PS01021; COPROGEN_OXIDASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Oxidoreductase; Porphyrin biosynthesis.
FT   CHAIN         1    290       Coproporphyrinogen-III oxidase, aerobic.
FT                                /FTId=PRO_0000109891.
SQ   SEQUENCE   290 AA;  32788 MW;  3C710AD41390325C CRC64;
     MSTDQDLDTK KAAARAWFES LRDQICAAFE QLEDEAPADL YPGAPGRFAK KAWDRPAGGG
     GVMGMMHGRL FEKVGVHVST VFGTFTPEMA KTMPGAAEDP RFFATGISLI AHMTNPRVPA
     VHMNTRFIAT TKSWFGGGGD LTPLLGYQRQ QDFPDAIDFH AAYKRACDKY DPEWHPKYKA
     WCDEYFFLPH RNEPRGIGGI FYDHHDSGDW ARDFAFTQDV GRAFLEIYPT LVRRRMGEAW
     TADEREQQLI QRGRYVEFNL LYDRGTMFGL KTGGNVESIL SSMPPAVKWP
//