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Q9AAT8 (HEM6_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:CC_0506
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_0000109891

Regions

Region64 – 7310Important for dimerization By similarity
Region124 – 1263Substrate binding By similarity
Region255 – 29036Important for dimerization By similarity
Region273 – 2786Substrate binding By similarity

Sites

Active site1221Proton donor By similarity
Binding site1081Substrate By similarity
Site1901Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9AAT8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3C710AD41390325C

FASTA29032,788
        10         20         30         40         50         60 
MSTDQDLDTK KAAARAWFES LRDQICAAFE QLEDEAPADL YPGAPGRFAK KAWDRPAGGG 

        70         80         90        100        110        120 
GVMGMMHGRL FEKVGVHVST VFGTFTPEMA KTMPGAAEDP RFFATGISLI AHMTNPRVPA 

       130        140        150        160        170        180 
VHMNTRFIAT TKSWFGGGGD LTPLLGYQRQ QDFPDAIDFH AAYKRACDKY DPEWHPKYKA 

       190        200        210        220        230        240 
WCDEYFFLPH RNEPRGIGGI FYDHHDSGDW ARDFAFTQDV GRAFLEIYPT LVRRRMGEAW 

       250        260        270        280        290 
TADEREQQLI QRGRYVEFNL LYDRGTMFGL KTGGNVESIL SSMPPAVKWP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK22493.1.
PIRA87312.
RefSeqNP_419325.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9AAT8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID941864.
GenomeReviewsGene locus CC_0506 in contig AE005673_GR.
KEGGccr:CC_0506.
NMPDRfig|190650.1.peg.505.
PATRIC21297958. VBICauCre124313_0516.
TIGRCC_0506.

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_CAUCR
AccessionPrimary (citable) accession number: Q9AAT8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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