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Protein

Homoserine O-acetyltransferase

Gene

metX

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (CC_3204), Homoserine O-acetyltransferase (metX)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551NucleophileUniRule annotation
Active sitei321 – 3211UniRule annotation
Active sitei354 – 3541UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciCAULO:CC0525-MONOMER.
UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERicaucr-CC0525. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Alternative name(s):
Homoserine O-trans-acetylaseUniRule annotation
Short name:
HTAUniRule annotation
Short name:
Homoserine transacetylaseUniRule annotation
Gene namesi
Name:metXUniRule annotation
Ordered Locus Names:CC_0525
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Homoserine O-acetyltransferasePRO_0000155710Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_0525.

Structurei

3D structure databases

ProteinModelPortaliQ9AAS1.
SMRiQ9AAS1. Positions 16-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. HTA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiEOG67T5J4.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
HAMAPiMF_00296. Homoser_O_acetyltr.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AAS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALDPITPA GGGTWRFPAN EPLRLDSGGV IEGLEIAYQT YGQLNADKSN
60 70 80 90 100
AVLICHALTG DQHVASPHPT TGKPGWWQRL VGPGKPLDPA RHFIICSNVI
110 120 130 140 150
GGCMGSTGPA SINPATGKTY GLSFPVITIA DMVRAQAMLV SALGVETLFA
160 170 180 190 200
VVGGSMGGMQ VQQWAVDYPE RMFSAVVLAS ASRHSAQNIA FHEVGRQAIM
210 220 230 240 250
ADPDWRGGAY AEHGVRPEKG LAVARMAAHI TYLSEPALQR KFGRELQRDG
260 270 280 290 300
LSWGFDADFQ VESYLRHQGS SFVDRFDANS YLYITRAMDY FDIAASHGGV
310 320 330 340 350
LAKAFTRARN VRFCVLSFSS DWLYPTAENR HLVRALTAAG ARAAFAEIES
360 370 380
DKGHDAFLLD EPVMDAALEG FLASAERDRG LV
Length:382
Mass (Da):41,216
Last modified:June 1, 2001 - v1
Checksum:i2C281B9B0E66BA07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22512.1.
PIRiD87314.
RefSeqiNP_419344.1. NC_002696.2.
WP_010918413.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22512; AAK22512; CC_0525.
GeneIDi941825.
KEGGiccr:CC_0525.
PATRICi21297996. VBICauCre124313_0535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22512.1.
PIRiD87314.
RefSeqiNP_419344.1. NC_002696.2.
WP_010918413.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9AAS1.
SMRiQ9AAS1. Positions 16-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0525.

Protein family/group databases

ESTHERicaucr-CC0525. Homoserine_transacetylase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22512; AAK22512; CC_0525.
GeneIDi941825.
KEGGiccr:CC_0525.
PATRICi21297996. VBICauCre124313_0535.

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiEOG67T5J4.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.
BioCyciCAULO:CC0525-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
HAMAPiMF_00296. Homoser_O_acetyltr.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiMETX_CAUCR
AccessioniPrimary (citable) accession number: Q9AAS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.