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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation1 Publication

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation1 Publication

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei155NucleophileUniRule annotation1
Binding sitei225SubstrateUniRule annotation1
Active sitei321UniRule annotation1
Active sitei354UniRule annotation1
Binding sitei355SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciCAULO:CC0525-MONOMER.
UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERicaucr-CC0525. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation1 Publication)
Short name:
HAT1 PublicationUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXA1 PublicationUniRule annotation
Ordered Locus Names:CC_0525
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557101 – 382Homoserine O-acetyltransferaseAdd BLAST382

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_0525.

Structurei

3D structure databases

ProteinModelPortaliQ9AAS1.
SMRiQ9AAS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 360AB hydrolase-1UniRule annotationAdd BLAST311

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoser/ser_AcTrfase.
IPR034387. Homoser_AcTrfase.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9AAS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALDPITPA GGGTWRFPAN EPLRLDSGGV IEGLEIAYQT YGQLNADKSN
60 70 80 90 100
AVLICHALTG DQHVASPHPT TGKPGWWQRL VGPGKPLDPA RHFIICSNVI
110 120 130 140 150
GGCMGSTGPA SINPATGKTY GLSFPVITIA DMVRAQAMLV SALGVETLFA
160 170 180 190 200
VVGGSMGGMQ VQQWAVDYPE RMFSAVVLAS ASRHSAQNIA FHEVGRQAIM
210 220 230 240 250
ADPDWRGGAY AEHGVRPEKG LAVARMAAHI TYLSEPALQR KFGRELQRDG
260 270 280 290 300
LSWGFDADFQ VESYLRHQGS SFVDRFDANS YLYITRAMDY FDIAASHGGV
310 320 330 340 350
LAKAFTRARN VRFCVLSFSS DWLYPTAENR HLVRALTAAG ARAAFAEIES
360 370 380
DKGHDAFLLD EPVMDAALEG FLASAERDRG LV
Length:382
Mass (Da):41,216
Last modified:June 1, 2001 - v1
Checksum:i2C281B9B0E66BA07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22512.1.
PIRiD87314.
RefSeqiNP_419344.1. NC_002696.2.
WP_010918413.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22512; AAK22512; CC_0525.
GeneIDi941825.
KEGGiccr:CC_0525.
PATRICifig|190650.5.peg.535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22512.1.
PIRiD87314.
RefSeqiNP_419344.1. NC_002696.2.
WP_010918413.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9AAS1.
SMRiQ9AAS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0525.

Protein family/group databases

ESTHERicaucr-CC0525. Homoserine_transacetylase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22512; AAK22512; CC_0525.
GeneIDi941825.
KEGGiccr:CC_0525.
PATRICifig|190650.5.peg.535.

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.
BioCyciCAULO:CC0525-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoser/ser_AcTrfase.
IPR034387. Homoser_AcTrfase.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETXA_CAUCR
AccessioniPrimary (citable) accession number: Q9AAS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.