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Protein

Dihydroorotate dehydrogenase (quinone)

Gene

CC_0528

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.SAAS annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.SAAS annotation

Pathway:iUMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydroorotate dehydrogenase (quinone) (CC_0528)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route), the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Biological processi

Pyrimidine biosynthesisSAAS annotation

Keywords - Ligandi

Flavoprotein, FMNSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone)SAAS annotation (EC:1.3.-.-SAAS annotation, EC:1.3.5.2SAAS annotation)
Gene namesi
Ordered Locus Names:CC_0528Imported
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)Imported
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816 Componenti: Chromosome

Subcellular locationi

  • Cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Subunit structurei

Monomer.SAAS annotation

Protein-protein interaction databases

STRINGi190650.CC_0528.

Structurei

3D structure databases

ProteinModelPortaliQ9AAR8.
SMRiQ9AAR8. Positions 14-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225103.
KOiK00254.
OMAiVYEGPGL.
OrthoDBiEOG65BDN8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9AAR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHDIAARA LHAFDPEDAH GWAIRGLKWG LGPRDAQPDD PILAVKIAGL
60 70 80 90 100
ELPNCVGLAA GFDKNAEVPD AMLAAGFGFV EAGTVTPLAQ AGNPRPRLFR
110 120 130 140 150
LTEDQAVINR MGFNNGGLEP FAQRLAARQG RGGVVGANIG ANKDATDRIQ
160 170 180 190 200
DYVTGLTRLW GLSDYFTANI SSPNTPGLRA LQTKAALEEL LGRLAETRAA
210 220 230 240 250
LKVASGADYP IFLKVAPDLE DGEVEAIVET VVGAGLDAII VSNTTIARPE
260 270 280 290 300
TLKSRFAGES GGLSGAPLLE ASTAVLARFH AAAAGRVALI GAGGVADGAG
310 320 330 340 350
AYAKIRAGAR AVQLYSALVY GGPGLVTRIK RDLAARLRAD GFAAVEDAIG

AA
Length:352
Mass (Da):36,320
Last modified:June 1, 2001 - v1
Checksum:iA53E5216089C2FF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22515.1.
PIRiG87314.
RefSeqiNP_419347.1. NC_002696.2.
WP_010918416.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22515; AAK22515; CC_0528.
GeneIDi941814.
KEGGiccr:CC_0528.
PATRICi21298002. VBICauCre124313_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22515.1.
PIRiG87314.
RefSeqiNP_419347.1. NC_002696.2.
WP_010918416.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9AAR8.
SMRiQ9AAR8. Positions 14-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22515; AAK22515; CC_0528.
GeneIDi941814.
KEGGiccr:CC_0528.
PATRICi21298002. VBICauCre124313_0538.

Phylogenomic databases

HOGENOMiHOG000225103.
KOiK00254.
OMAiVYEGPGL.
OrthoDBiEOG65BDN8.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15Imported.

Entry informationi

Entry nameiQ9AAR8_CAUCR
AccessioniPrimary (citable) accession number: Q9AAR8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.