Q9AAR8 (Q9AAR8_CAUCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotate dehydrogenase EMBL AAK22515.1

Gene names

Ordered Locus Names:

CC_0528

Organism

Caulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]

Taxonomic identifier

190650 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter crescentus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135
Catalytic activity	(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135
Cofactor	Binds 1 FMN per subunit By similarity. SAAS SAAS012135
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135
Subunit structure	Monomer By similarity. SAAS SAAS012135

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS012135
Cellular component	Membrane SAAS SAAS012135
Ligand	FMN SAAS SAAS012135 Flavoprotein SAAS SAAS012135
Molecular function	Oxidoreductase SAAS SAAS012135
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9AAR8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A53E5216089C2FF9	FASTA	352	36,320
	10 20 30 40 50 60 MSLHDIAARA LHAFDPEDAH GWAIRGLKWG LGPRDAQPDD PILAVKIAGL ELPNCVGLAA 70 80 90 100 110 120 GFDKNAEVPD AMLAAGFGFV EAGTVTPLAQ AGNPRPRLFR LTEDQAVINR MGFNNGGLEP 130 140 150 160 170 180 FAQRLAARQG RGGVVGANIG ANKDATDRIQ DYVTGLTRLW GLSDYFTANI SSPNTPGLRA 190 200 210 220 230 240 LQTKAALEEL LGRLAETRAA LKVASGADYP IFLKVAPDLE DGEVEAIVET VVGAGLDAII 250 260 270 280 290 300 VSNTTIARPE TLKSRFAGES GGLSGAPLLE ASTAVLARFH AAAAGRVALI GAGGVADGAG 310 320 330 340 350 AYAKIRAGAR AVQLYSALVY GGPGLVTRIK RDLAARLRAD GFAAVEDAIG AA

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK22515.1.
PIR	G87314.
RefSeq	NP_419347.1. NC_002696.2.
3D structure databases
HSSP	HSSP built from PDB template 1D3G based on UniProtKB Q02127.
ProteinModelPortal	Q9AAR8.
SMR	Q9AAR8. Positions 14-351.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK22515; AAK22515; CC_0528.
GeneID	941814.
KEGG	ccr:CC_0528.
PATRIC	21298002. VBICauCre124313_0538.
Phylogenomic databases
HOGENOM	HOG000225103.
KO	K00226.
OMA	ALNRMGF.
ProtClustDB	PRK05286.
Enzyme and pathway databases
UniPathway	UPA00070; UER00946.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR012135. Dihydroorotate_DH_1_2. IPR005719. Dihydroorotate_DH_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01036. pyrD_sub2. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9AAR8_CAUCR

Accession

Primary (citable) accession number: Q9AAR8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)