ID   Q9AAQ2_CAUVC            Unreviewed;       695 AA.
AC   Q9AAQ2;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=Nuclease, putative {ECO:0000313|EMBL:AAK22531.1};
GN   OrderedLocusNames=CC_0544 {ECO:0000313|EMBL:AAK22531.1};
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650 {ECO:0000313|EMBL:AAK22531.1, ECO:0000313|Proteomes:UP000001816};
RN   [1] {ECO:0000313|EMBL:AAK22531.1, ECO:0000313|Proteomes:UP000001816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15 {ECO:0000313|Proteomes:UP000001816};
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R., Ohta N., Maddock J.R., Potocka I.,
RA   Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T.,
RA   Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J.,
RA   Craven M.B., Khouri H., Shetty J., Berry K., Utterback T., Tran K.,
RA   Wolf A., Vamathevan J., Ermolaeva M., White O., Salzberg S.L., Venter J.C.,
RA   Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
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DR   EMBL; AE005673; AAK22531.1; -; Genomic_DNA.
DR   PIR; G87316; G87316.
DR   RefSeq; NP_419363.1; NC_002696.2.
DR   AlphaFoldDB; Q9AAQ2; -.
DR   SMR; Q9AAQ2; -.
DR   STRING; 190650.CC_0544; -.
DR   EnsemblBacteria; AAK22531; AAK22531; CC_0544.
DR   KEGG; ccr:CC_0544; -.
DR   PATRIC; fig|190650.5.peg.554; -.
DR   eggNOG; COG1864; Bacteria.
DR   eggNOG; COG3591; Bacteria.
DR   HOGENOM; CLU_016161_0_0_5; -.
DR   BioCyc; CAULO:CC0544-MONOMER; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd00091; NUC; 1.
DR   Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR   InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR   InterPro; IPR020821; Extracellular_endonuc_su_A.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   InterPro; IPR040255; Non-specific_endonuclease.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   PANTHER; PTHR13966:SF5; ENDONUCLEASE G, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13966; ENDONUCLEASE RELATED; 1.
DR   Pfam; PF01223; Endonuclease_NS; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   SMART; SM00892; Endonuclease_NS; 1.
DR   SMART; SM00477; NUC; 1.
DR   SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR640255-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001816}.
FT   DOMAIN          441..665
FT                   /note="DNA/RNA non-specific endonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00892"
FT   DOMAIN          442..665
FT                   /note="Extracellular Endonuclease subunit A"
FT                   /evidence="ECO:0000259|SMART:SM00477"
FT   REGION          14..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        504
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640255-1"
FT   BINDING         538
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640255-2"
SQ   SEQUENCE   695 AA;  75593 MW;  6CF7586595A951FD CRC64;
     MAIAAALDPR RLRSPIGDPG YRTRRDASIM SDKMEESRSR LESLLPRLGK AAERLARDGG
     ESVRALGLRS PVLDAETLTR ALDAGPGKLE SVGVNPMALE AIIRLTGRPP LIVRNDAVVI
     EPPLLEEFPI TITGQIKAVE PALASVGRIE FVNHEMAWGG TGWVVDSGAD SALVVTNRHV
     AKLVAKRSAD GRGVFLRSPY SGARYGASID FNEEVDARVT DARNASATAV EYLADDTGAD
     VALLRIKRPL NAAWAWPDSV PLADQEAGLE ELVALIGYPA YDTRNDVTAM ERYFRGLYDV
     KRFAPGRVTR AADSGGVISH DCTSLGGNSG SVLLSLERRV AVGLHFAGQY GIANSAVSAA
     TLRRLVFGSR TTVAGAVLQE TFVEAKDGLH TADDLKDREG YVPGFLGKTT PPVPWPTLAP
     EIAAGLAKPV DALPGRPHEL RYTHFGVLFS QDLKLPAATA VNIDGKQPVR IKRGDDKWFV
     DARIDPACQY TAKHYGDQAI DRGHMVRRED PNWGDDAIQA NFDTFHYTNA APQHALLNQG
     KSLWQGLENY ILDNSRTEGF KACVFTGPIL NGDYEYLPEE GDVRVPLEFW KVAVMTAKTE
     DGQDTLHATA YVLSQGHLIR KLLEDRQRSE ALEGFRLGAY RTFQVAIRDL EAATGMNFHD
     LRNYDPLAAT KAGSEAIAQD EPVFVPLETA ADLVL
//