ID   ASTD1_CAUCR             Reviewed;         472 AA.
AC   Q9AAL5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase 1;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase 1;
DE            Short=SGSD 1;
GN   Name=astD1; OrderedLocusNames=CC_0582;
OS   Caulobacter crescentus (Caulobacter vibrioides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   MEDLINE=21173698; PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H.,
RA   Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J.,
RA   Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J.,
RA   Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L.,
RA   Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; AE005673; AAK22568.1; -; Genomic_DNA.
DR   PIR; D87321; D87321.
DR   RefSeq; NP_419400.1; -.
DR   HSSP; P56533; 1A4S.
DR   GeneID; 941719; -.
DR   GenomeReviews; AE005673_GR; CC_0582.
DR   KEGG; ccr:CC_0582; -.
DR   NMPDR; fig|190650.1.peg.580; -.
DR   TIGR; CC_0582; -.
DR   HOGENOM; Q9AAL5; -.
DR   BRENDA; 1.2.1.71; 2191.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    472       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase 1.
FT                                /FTId=PRO_0000262394.
FT   NP_BIND     209    214       NAD (By similarity).
FT   ACT_SITE    232    232       By similarity.
FT   ACT_SITE    266    266       By similarity.
SQ   SEQUENCE   472 AA;  49811 MW;  28E7C4A5FF80EF2F CRC64;
     MSASRLISRD PYTGEAIADF AVNDARSIDA ACHSARAAFA EWAMTPLAER RAIALRFAET
     VRARREEIAT LIARETGKPM WEALTEADSV AAKVAISIRA QDERAGERSE PMADATARLA
     HRPHGVLAVI GPFNFPMHLA NGHIVPALLA GNAVVFKPSE KTPACGQLMG ELWRAAGLPD
     HVLTIVIGGG EAGEALVRHE ALDGVLFTGG VQAGRAIHRA LADAPHKILA LELGGNAPLV
     VWDVADIEAA AHLIVQSAYV TAGQRCTCAR RLILPEGARG DALLEALTML MDRLVIGGPF
     QSPAPFMGPV IDAHAAAQVL AAQDRMTADG GRPLRLAAVR EARSALLSPG LIELTDAPLR
     DEEIFGPLLQ VRRAADFDAA LALANATRFG LAAGLISDDE ALYRRFWTSV RAGIVNWNRP
     TTGASSAAPF GGVGGSGNHR PSAYYAADYS AYPVAGLESP SPVYRLPIGL NP
//