Reviewed, UniProtKB/Swiss-Prot Q9AAL5 (ASTD1_CAUCR)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 1
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 1
      Short name=SGSD 1

Gene names

Name:	astD1
Ordered Locus Names:	CC_0582

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	N-succinylglutamate 5-semialdehyde dehydrogenase 1 HAMAP MF_01174		PRO_0000262394
Regions
	Nucleotide binding	209 – 214	6	NAD By similarity
Sites
	Active site	232	1	By similarity
	Active site	266	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9AAL5-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 28E7C4A5FF80EF2F	FASTA	472	49,811
	10 20 30 40 50 60 MSASRLISRD PYTGEAIADF AVNDARSIDA ACHSARAAFA EWAMTPLAER RAIALRFAET 70 80 90 100 110 120 VRARREEIAT LIARETGKPM WEALTEADSV AAKVAISIRA QDERAGERSE PMADATARLA 130 140 150 160 170 180 HRPHGVLAVI GPFNFPMHLA NGHIVPALLA GNAVVFKPSE KTPACGQLMG ELWRAAGLPD 190 200 210 220 230 240 HVLTIVIGGG EAGEALVRHE ALDGVLFTGG VQAGRAIHRA LADAPHKILA LELGGNAPLV 250 260 270 280 290 300 VWDVADIEAA AHLIVQSAYV TAGQRCTCAR RLILPEGARG DALLEALTML MDRLVIGGPF 310 320 330 340 350 360 QSPAPFMGPV IDAHAAAQVL AAQDRMTADG GRPLRLAAVR EARSALLSPG LIELTDAPLR 370 380 390 400 410 420 DEEIFGPLLQ VRRAADFDAA LALANATRFG LAAGLISDDE ALYRRFWTSV RAGIVNWNRP 430 440 450 460 470 TTGASSAAPF GGVGGSGNHR PSAYYAADYS AYPVAGLESP SPVYRLPIGL NP

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK22568.1.
PIR	D87321.
RefSeq	NP_419400.1.
3D structure databases
SMR	Q9AAL5. Positions 5-448.
ModBase	Search...
Genome annotation databases
GeneID	941719.
GenomeReviews	Gene locus CC_0582 in contig AE005673_GR.
KEGG	ccr:CC_0582.
NMPDR	fig|190650.1.peg.580.
TIGR	CC_0582.
Phylogenomic databases
HOGENOM	HBG752218.
OMA	DISILAY.
Enzyme and pathway databases
BRENDA	1.2.1.71. 2191.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD1_CAUCR

Accession

Primary (citable) accession number: Q9AAL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)