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Q9AAL5 (ASTD1_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase 1
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase 1
Short name=SGSD 1
Gene names
Name:astD1
Ordered Locus Names:CC_0582
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472N-succinylglutamate 5-semialdehyde dehydrogenase 1 HAMAP MF_01174
PRO_0000262394

Regions

Nucleotide binding209 – 2146NAD By similarity

Sites

Active site2321 By similarity
Active site2661 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9AAL5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 28E7C4A5FF80EF2F

FASTA47249,811
        10         20         30         40         50         60 
MSASRLISRD PYTGEAIADF AVNDARSIDA ACHSARAAFA EWAMTPLAER RAIALRFAET 

        70         80         90        100        110        120 
VRARREEIAT LIARETGKPM WEALTEADSV AAKVAISIRA QDERAGERSE PMADATARLA 

       130        140        150        160        170        180 
HRPHGVLAVI GPFNFPMHLA NGHIVPALLA GNAVVFKPSE KTPACGQLMG ELWRAAGLPD 

       190        200        210        220        230        240 
HVLTIVIGGG EAGEALVRHE ALDGVLFTGG VQAGRAIHRA LADAPHKILA LELGGNAPLV 

       250        260        270        280        290        300 
VWDVADIEAA AHLIVQSAYV TAGQRCTCAR RLILPEGARG DALLEALTML MDRLVIGGPF 

       310        320        330        340        350        360 
QSPAPFMGPV IDAHAAAQVL AAQDRMTADG GRPLRLAAVR EARSALLSPG LIELTDAPLR 

       370        380        390        400        410        420 
DEEIFGPLLQ VRRAADFDAA LALANATRFG LAAGLISDDE ALYRRFWTSV RAGIVNWNRP 

       430        440        450        460        470 
TTGASSAAPF GGVGGSGNHR PSAYYAADYS AYPVAGLESP SPVYRLPIGL NP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK22568.1.
PIRD87321.
RefSeqNP_419400.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9AAL5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID941719.
GenomeReviewsGene locus CC_0582 in contig AE005673_GR.
KEGGccr:CC_0582.
NMPDRfig|190650.1.peg.580.
PATRIC21298116. VBICauCre124313_0594.
TIGRCC_0582.

Phylogenomic databases

HOGENOMHBG752218.
OMAMGPVIDN.
ProtClustDBCLSK2461052.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD1_CAUCR
AccessionPrimary (citable) accession number: Q9AAL5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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