Q9AAL4 (ASTB1_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylarginine dihydrolase 1
EC=3.5.3.23

Gene names

Name:	astB1
Ordered Locus Names:	CC_0583

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO2 By similarity. HAMAP MF_01172
Catalytic activity	N(2)-succinyl-L-arginine + 2 H2O = N(2)-succinyl-L-ornithine + 2 NH3 + CO2. HAMAP MF_01172
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5. HAMAP MF_01172
Subunit structure	Homodimer By similarity. HAMAP MF_01172
Sequence similarities	Belongs to the succinylarginine dihydrolase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-succinylarginine dihydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	N-succinylarginine dihydrolase 1 HAMAP MF_01172		PRO_0000262345
Regions
	Region	18 – 27	10	Substrate binding By similarity
	Region	136 – 137	2	Substrate binding By similarity
Sites
	Active site	172	1	By similarity
	Active site	240	1	By similarity
	Active site	355	1	Nucleophile By similarity
	Binding site	109	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	349	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9AAL4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FDF973EB1AF4E80E	FASTA	426	45,017
	10 20 30 40 50 60 MTLEINFDGL IGPTHNYAGL SLGNIASHSN AGAVSSPRAA ALQGLTKMRT LLDLGLTQGF 70 80 90 100 110 120 LPPPPRPAAH VLRRLGFKGS DQAVLAQVAD EDLDLLRAAS SASSMWTANA ATVLAAPDTA 130 140 150 160 170 180 DGRVHLVTAN LGTMLHRSLE ADDTYATLRR VFSGEAFAVH APLPFAAHLG DEGAANHMRL 190 200 210 220 230 240 AANHGARGVN VFVHGAPRGG RFPERQALRA SQAAARLAGV QPTALFAMQS AEAIKAGAFH 250 260 270 280 290 300 NDVVAVANAN VLLAHPQAFA TRPDLLAELS ARLPGLVVIE TRDLSLEDAV ASYLFNSQLV 310 320 330 340 350 360 SLPDGYMALI VPVEARDNAA AWREIQTILA ADNPVTKVKV VDLRQSMSNG GGPACLRLRV 370 380 390 400 410 420 PVAAAARDQI NPAFLLDHAR LDRLTRLVET WWPRAIAPSD LTDPALWEAA MVAHAALETF LTAPTV

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK22569.1.
PIR	E87321.
RefSeq	NP_419401.1. NC_002696.2.
3D structure databases
HSSP	HSSP built from PDB template 1YNF based on UniProtKB P76216.
ProteinModelPortal	Q9AAL4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	941706.
GenomeReviews	Gene locus CC_0583 in contig AE005673_GR.
KEGG	ccr:CC_0583.
NMPDR	fig|190650.1.peg.581.
PATRIC	21298118. VBICauCre124313_0595.
TIGR	CC_0583.
Phylogenomic databases
HOGENOM	HBG289862.
OMA	ANHMRIT.
ProtClustDB	PRK13281.
Family and domain databases
HAMAP	MF_01172. AstB. [Tree]
InterPro	IPR007079. SuccinylArg_d-Hdrlase_AstB. [Graphical view]
Gene3D	G3DSA:3.75.10.20. SuccinylArg_di_hydro. 1 hit.
KO	K01484.
Pfam	PF04996. AstB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTB1_CAUCR

Accession

Primary (citable) accession number: Q9AAL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program