Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toxin ParE1

Gene

parE1

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Toxic component of a toxin-antitoxin (TA) module. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD1 but no other ParD or RelB antitoxin. Low levels of wild-type toxin in the absence of antitoxin decreases the rate of cell growth, and results in death or loss of colony formation abilities and greatly elongated cells. Low levels of a mutant missing the last 4 residues leads to loss of cell division while cell elongation continues.1 Publication

GO - Biological processi

  • protein heterotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Enzyme and pathway databases

BioCyciCAULO:CC0873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin ParE1
Gene namesi
Name:parE1
Ordered Locus Names:CC_0873
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

No visible phenotype when deleted singly or as the parDE1 operon.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi87 – 9610Missing : No longer toxic; protein is significantly less stable. 1 Publication
Mutagenesisi93 – 964Missing : Decreased toxicity; protein is less stable. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9696Toxin ParE1PRO_0000408368Add
BLAST

Interactioni

Subunit structurei

Forms a ParD12-ParE12 heterotetramer.1 Publication

Protein-protein interaction databases

STRINGi190650.CC_0873.

Structurei

Secondary structure

1
96
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi8 – 2518Combined sources
Helixi27 – 4620Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 533Combined sources
Turni55 – 573Combined sources
Beta strandi61 – 677Combined sources
Beta strandi69 – 8618Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60A/B1-96[»]
ProteinModelPortaliQ9A9T8.
SMRiQ9A9T8. Positions 2-95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9A9T8.

Family & Domainsi

Sequence similaritiesi

Belongs to the RelE toxin family.Curated

Phylogenomic databases

eggNOGiENOG4105VV5. Bacteria.
COG3668. LUCA.
HOGENOMiHOG000138821.
KOiK19092.
OMAiRIWDDSA.

Family and domain databases

InterProiIPR028344. ParE1/4.
IPR007712. RelE/ParE_toxin.
[Graphical view]
PfamiPF05016. ParE_toxin. 1 hit.
[Graphical view]
PIRSFiPIRSF029218. ParE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9A9T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPYRLSRRA KADLDDIWTY SEQRWGVEQA ADYARELQAT IEMIAEHPGM
60 70 80 90
GQPDENLRAG YRRCASGSHV VFYRVGVRVE IIRVLHQSMN ARAHLG
Length:96
Mass (Da):11,058
Last modified:June 1, 2001 - v1
Checksum:iABE5EEB28FBC1E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22858.1.
PIRiF87357.
RefSeqiNP_419690.1. NC_002696.2.
WP_010918758.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22858; AAK22858; CC_0873.
GeneIDi941174.
KEGGiccr:CC_0873.
PATRICi21298704. VBICauCre124313_0886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22858.1.
PIRiF87357.
RefSeqiNP_419690.1. NC_002696.2.
WP_010918758.1. NC_002696.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60A/B1-96[»]
ProteinModelPortaliQ9A9T8.
SMRiQ9A9T8. Positions 2-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0873.

Protocols and materials databases

DNASUi941174.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22858; AAK22858; CC_0873.
GeneIDi941174.
KEGGiccr:CC_0873.
PATRICi21298704. VBICauCre124313_0886.

Phylogenomic databases

eggNOGiENOG4105VV5. Bacteria.
COG3668. LUCA.
HOGENOMiHOG000138821.
KOiK19092.
OMAiRIWDDSA.

Enzyme and pathway databases

BioCyciCAULO:CC0873-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9A9T8.

Family and domain databases

InterProiIPR028344. ParE1/4.
IPR007712. RelE/ParE_toxin.
[Graphical view]
PfamiPF05016. ParE_toxin. 1 hit.
[Graphical view]
PIRSFiPIRSF029218. ParE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPARE1_CAUCR
AccessioniPrimary (citable) accession number: Q9A9T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.