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Protein

Toxin ParE1

Gene

parE1

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD1 but no other ParD or RelB antitoxin. Low levels of wild-type toxin in the absence of antitoxin decreases the rate of cell growth, and results in death or loss of colony formation abilities and greatly elongated cells. Low levels of a mutant missing the last 4 residues leads to loss of cell division while cell elongation continues.1 Publication

GO - Biological processi

  • protein heterotetramerization Source: UniProtKB

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciCAULO:CC0873-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin ParE1
Gene namesi
Name:parE1
Ordered Locus Names:CC_0873
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

No visible phenotype when deleted singly or as the parDE1 operon.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87 – 96Missing : No longer toxic; protein is significantly less stable. 1 Publication10
Mutagenesisi93 – 96Missing : Decreased toxicity; protein is less stable. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004083681 – 96Toxin ParE1Add BLAST96

Interactioni

Subunit structurei

Forms a ParD12-ParE12 heterotetramer.1 Publication

Protein-protein interaction databases

STRINGi190650.CC_0873

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi8 – 25Combined sources18
Helixi27 – 46Combined sources20
Helixi48 – 50Combined sources3
Beta strandi51 – 53Combined sources3
Turni55 – 57Combined sources3
Beta strandi61 – 67Combined sources7
Beta strandi69 – 86Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60A/B1-96[»]
ProteinModelPortaliQ9A9T8
SMRiQ9A9T8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9A9T8

Family & Domainsi

Sequence similaritiesi

Belongs to the RelE toxin family.Curated

Phylogenomic databases

eggNOGiENOG4105VV5 Bacteria
COG3668 LUCA
HOGENOMiHOG000138821
KOiK19092
OMAiRILHGRM

Family and domain databases

Gene3Di3.30.2310.20, 1 hit
InterProiView protein in InterPro
IPR028344 ParE1/4
IPR007712 RelE/ParE_toxin
IPR035093 RelE/ParE_toxin_dom_sf
PfamiView protein in Pfam
PF05016 ParE_toxin, 1 hit
PIRSFiPIRSF029218 ParE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A9T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPYRLSRRA KADLDDIWTY SEQRWGVEQA ADYARELQAT IEMIAEHPGM
60 70 80 90
GQPDENLRAG YRRCASGSHV VFYRVGVRVE IIRVLHQSMN ARAHLG
Length:96
Mass (Da):11,058
Last modified:June 1, 2001 - v1
Checksum:iABE5EEB28FBC1E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22858.1
PIRiF87357
RefSeqiNP_419690.1, NC_002696.2
WP_010918758.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22858; AAK22858; CC_0873
GeneIDi941174
KEGGiccr:CC_0873
PATRICifig|190650.5.peg.886

Similar proteinsi

Entry informationi

Entry nameiPARE1_CAUVC
AccessioniPrimary (citable) accession number: Q9A9T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health