Reviewed, UniProtKB/Swiss-Prot Q9A9I6 (MSRA1_CAUCR)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 1
      Short name=Protein-methionine-S-oxide reductase 1
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 1
      Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	CC_0994

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Peptide methionine sulfoxide reductase msrA 1 HAMAP MF_01401		PRO_0000138536
Sites
	Active site	54	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A9I6-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: ED945F0AA9FD933B	FASTA	217	23,044
	10 20 30 40 50 60 MLSLHKTLEM PSADTALPGR AAPIPTAQTH FVNGHALKGP YPEGLETAIV AMGCFWGVER 70 80 90 100 110 120 VFWKVPGVYV TAAGYAAGIT PNPTYEEVCT GRTGHTEVVL VVFDPKVVTY EALLKTFWEN 130 140 150 160 170 180 HDPTQGMRQG NDIGTQYRSG LYVTSDAQAA AAAESKAAYQ QALSARGLGT ITTEIAPAGP 190 200 210 FYFAEDYHQQ YLAKNPNGYC GIGGTGVVCP IGLGVEG

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK22978.1.
PIR	F87372.
RefSeq	NP_419810.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P27110.
ModBase	Search...
Genome annotation databases
GeneID	942718.
GenomeReviews	Gene locus CC_0994 in contig AE005673_GR.
KEGG	ccr:CC_0994.
NMPDR	fig|190650.1.peg.990.
TIGR	CC_0994.
Phylogenomic databases
HOGENOM	Q9A9I6.
OMA	Q9A9I6. PFYFAED.
Enzyme and pathway databases
BRENDA	1.8.4.11. 2191.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_CAUCR

Accession

Primary (citable) accession number: Q9A9I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)