ID   MSRA2_CAUCR             Reviewed;         196 AA.
AC   Q9A9E9;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrA 2;
DE            Short=Protein-methionine-S-oxide reductase 2;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase 2;
DE            Short=Peptide Met(O) reductase 2;
GN   Name=msrA2; OrderedLocusNames=CC_1039;
OS   Caulobacter crescentus (Caulobacter vibrioides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=155892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   MEDLINE=21173698; PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H.,
RA   Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J.,
RA   Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J.,
RA   Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L.,
RA   Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
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DR   EMBL; AE005673; AAK23023.1; -; Genomic_DNA.
DR   PIR; C87378; C87378.
DR   RefSeq; NP_419855.1; -.
DR   HSSP; P96814; 1NWA.
DR   GeneID; 940574; -.
DR   GenomeReviews; AE005673_GR; CC_1039.
DR   KEGG; ccr:CC_1039; -.
DR   NMPDR; fig|190650.1.peg.1035; -.
DR   TIGR; CC_1039; -.
DR   HOGENOM; Q9A9E9; -.
DR   OMA; Q9A9E9; HFYKKNP.
DR   BRENDA; 1.8.4.11; 2191.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006464; P:protein modification process; IEA:HAMAP.
DR   HAMAP; MF_01401; -; 1.
DR   InterPro; IPR002569; MsrA.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   ProDom; PD003489; PMSR; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    196       Peptide methionine sulfoxide reductase
FT                                msrA 2.
FT                                /FTId=PRO_0000138537.
FT   ACT_SITE     36     36       By similarity.
SQ   SEQUENCE   196 AA;  21916 MW;  A5A50429EA8D1217 CRC64;
     MRRLIVLFAA ALAVLGATAP ALAAPKTETA VFAGGCFWCM EHDMQGVPGV LKVESGYTGG
     HLKNPTYRDV TSETSGHYEA VRVTYDPAKL DYGFLLYRYW RLVDPTDDGG QFCDRGPSYR
     PAVFVTPAQR PIAEKSRTEA AKRLKTGTMK TQILPAQTFY LAEEYHRDYA KRNKLNYFAY
     RTGCGRDARL KQVWGG
//