Reviewed, UniProtKB/Swiss-Prot Q9A943 (LLDD_CAUCR)

Names and origin

Protein names

Recommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3

Gene names

Name:	lldD
Ordered Locus Names:	CC_1151

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559
Cofactor	FMN By similarity. HAMAP MF_01559
Sequence similarities	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	L-lactate dehydrogenase [cytochrome] HAMAP MF_01559		PRO_0000206333
Regions
	Domain	1 – 380	380	FMN hydroxy acid dehydrogenase
	Nucleotide binding	306 – 330	25	FMN By similarity
Sites
	Active site	275	1	Proton acceptor By similarity
	Binding site	24	1	Substrate Potential
	Binding site	106	1	FMN By similarity
	Binding site	127	1	FMN By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	155	1	FMN By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	251	1	FMN By similarity
	Binding site	278	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9A943-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F992AF018A637467	FASTA	383	40,720
	10 20 30 40 50 60 MIVSSTTDFR EAARRRLPRF LFDYIDGGAY AERTMARNID DLADIALRQR VLMDVSVVDP 70 80 90 100 110 120 STTLFGVRQA LPVALAPVGL TGMYARRGEC QAARAAAAKG VPFCLSTVSV CDVDEVRAAS 130 140 150 160 170 180 ATPFWFQLYV LRDRGFMRDL LARASAAGAT TLVFTVDMPV PGARYRDAHS GMSGPNAAAR 190 200 210 220 230 240 RLVQAALKPA WAWDVGVMGH PHRLGNVAPA LGKASGLQDF MGWLAANFDP SIQWSDLKWI 250 260 270 280 290 300 RDAWKGPLVI KGVLDPEDAK AAADIGADGV VVSNHGGRQL DGVLSSARAL PAIADAVGDR 310 320 330 340 350 360 LTVLADGGVR SGLDVVRMLA LGARGVLIGR AYAYALAARG EAGVTQLLDL IDKEMRVAMA 370 380 LTGVRDVASI NETILAERVP RAG

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23135.1.
PIR	C87392.
RefSeq	NP_419967.1.
3D structure databases
SMR	Q9A943. Positions 1-376.
ModBase	Search...
Genome annotation databases
GeneID	941645.
GenomeReviews	Gene locus CC_1151 in contig AE005673_GR.
KEGG	ccr:CC_1151.
NMPDR	fig|190650.1.peg.1147.
TIGR	CC_1151.
Phylogenomic databases
HOGENOM	HBG517781.
OMA	WIREFWE.
Enzyme and pathway databases
BRENDA	1.1.2.3. 2191.
Family and domain databases
HAMAP	MF_01559. L-lact_dehydr. [Tree]
InterPro	IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LLDD_CAUCR

Accession

Primary (citable) accession number: Q9A943

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)