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Q9A8L7 (ISPE_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Short name=CMK
EC=2.7.1.148
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name:ispE
Ordered Locus Names:CC_1336
OrganismCaulobacter crescentus (Caulobacter vibrioides)
Taxonomic identifier155892 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2952954-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
PRO_0000189201

Regions

Nucleotide binding101 – 11111ATP Potential

Sites

Active site151 By similarity
Active site1431 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A8L7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 255AB659FE703972

FASTA29530,905
        10         20         30         40         50         60 
MSHEIMRLSA FAPAKVNLFL HVGGPDGEGY HPISSLMVFA DVGDRVNLQP ADAPAFETSG 

        70         80         90        100        110        120 
PFGDQIPAGG DNLVVRAGQA FHRRLGGPVP PYRLILEKHL PIAAGLGGGS SDAGAALKLL 

       130        140        150        160        170        180 
RDALAPALSD DDLEALAASL GADGAACLRA RALIAEGRGE RLSPAPRLPE LNAVLVNPGA 

       190        200        210        220        230        240 
PSPTGAVYRA YDAGVHPDGA AMPPMPDHLE SAEEAAAWLA FATRNDLEAP AVRLEPHIGE 

       250        260        270        280        290 
VLDVLRGEPE SLLVRMSGSG ATCFALCASD IEAEGLAERL ETMRPDWWVR RCRLS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005673 Genomic DNA. Translation: AAK23317.1.
PIRA87415.
RefSeqNP_420149.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A8L7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID942489.
GenomeReviewsGene locus CC_1336 in contig AE005673_GR.
KEGGccr:CC_1336.
NMPDRfig|190650.1.peg.1329.
PATRIC21299686. VBICauCre124313_1365.
TIGRCC_1336.

Phylogenomic databases

HOGENOMHBG734593.
OMACQLARMS.
ProtClustDBPRK14608.

Family and domain databases

HAMAPMF_00061. IspE.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00919.
PANTHERPTHR20861:SF2. IspE. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. IspE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_CAUCR
AccessionPrimary (citable) accession number: Q9A8L7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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