Reviewed, UniProtKB/Swiss-Prot Q9A8L2 (SYGA_CAUCR)

Names and origin

Protein names

Recommended name:
    Glycyl-tRNA synthetase alpha subunit
    EC=6.1.1.14
Alternative name(s):
    Glycine--tRNA ligase alpha subunit
      Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	CC_1341

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity. HAMAP MF_00254
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Glycyl-tRNA synthetase alpha subunit HAMAP MF_00254		PRO_0000072834

Sequences

	Sequence		Length	Mass (Da)
	Q9A8L2-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: C41015AC2C94690F	FASTA	299	33,845
	10 20 30 40 50 60 MSREKPKSFQ SLILTLHDYW SRQGCVILQP HDVEVGAGTL HPATVLRALG PKAWNAAYVQ 70 80 90 100 110 120 PSRRPGDGRY GENPNRLQHY YQYQVILKPN PENMQDLYLG SLEAIGLDLR THDIRFVEDD 130 140 150 160 170 180 WENPTVGAWG LGWEVWCDGM EVSQYTYFQQ VGGLDVNPVA GELTYGLERL AMYVFGVDNV 190 200 210 220 230 240 YDLPFNDPDS PLGATTYGDV FLENERQQSE ANFHGFDVAV LKQQFEQMEE QVPLMLARSY 250 260 270 280 290 QDKALVLPAY DMVLKASHLF NLMNARGAIA VAERASYIGR IRDLCKMCAS AWVEQQEAA

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23322.1.
PIR	F87415.
RefSeq	NP_420154.1.
3D structure databases
SMR	Q9A8L2. Positions 8-297.
ModBase	Search...
Genome annotation databases
GeneID	941663.
GenomeReviews	Gene locus CC_1341 in contig AE005673_GR.
KEGG	ccr:CC_1341.
NMPDR	fig|190650.1.peg.1334.
TIGR	CC_1341.
Phylogenomic databases
HOGENOM	HBG285316.
OMA	CRRPTDG.
Enzyme and pathway databases
BRENDA	6.1.1.14. 2191.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. glyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_CAUCR

Accession

Primary (citable) accession number: Q9A8L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)