Q9A8H5 (ARGC_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CC_1378

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_0000112506
Sites
	Active site	118	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A8H5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FC798C7D3EE74561	FASTA	317	33,278
	10 20 30 40 50 60 MANAPKVFID GEAGTTGLQI RERLVGRTDL QLISIDPDKR KDADARAEML NSADAVILCL 70 80 90 100 110 120 PDDAAKEAVS LVSNPNTVII DASTAYRTAE GWAYGFAELD SEQRGKIAAS KRISNPGCYP 130 140 150 160 170 180 TGAIALTRPL VSAGILPAEL PVSYNAVSGY TGGGKAMIAQ FEDESAADHT RAPYFIYGLS 190 200 210 220 230 240 LSHKHVPEMQ KHGGLLTRPI FTPAVGRYAQ GMIVEMPLHL STLNGAPSLA DIHAALVKHY 250 260 270 280 290 300 KGEAFVEVAS LDEAKALTTL DPEGLNGTNR LKLFVFGSDA GGQARLVALL DNLGKGASGA 310 AVQNLNIALG LDEAAGL

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23359.1.
PIR	C87420.
RefSeq	NP_420191.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q9A8H5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	941717.
GenomeReviews	Gene locus CC_1378 in contig AE005673_GR.
KEGG	ccr:CC_1378.
NMPDR	fig|190650.1.peg.1371.
PATRIC	21299774. VBICauCre124313_1408.
TIGR	CC_1378.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	PIFVPSV.
ProtClustDB	PRK11863.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CAUCR

Accession

Primary (citable) accession number: Q9A8H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program