Q9A8G9 (F16PA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	CC_1385

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364517
Regions
	Region	120 – 123	4	Substrate binding By similarity
Sites
	Metal binding	98	1	Magnesium 1 By similarity
	Metal binding	117	1	Magnesium 1 By similarity
	Metal binding	117	1	Magnesium 2 By similarity
	Metal binding	119	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	120	1	Magnesium 2 By similarity
	Metal binding	282	1	Magnesium 2 By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	276	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A8G9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3D495D9542F1CC50	FASTA	336	35,734
	10 20 30 40 50 60 MGRSAFGSRT RMTAFVDLAA RLAAEPADAA LKDVVLTIAE TCAQISRVVA SGALSGSLGA 70 80 90 100 110 120 AGSTNVQDEE QKKLDVITND MLSDALKACG PVAGLASEEL EEVEPTGRVG GYLVTFDPLD 130 140 150 160 170 180 GSSNIDVNVS VGTIFSVLPA PAGHAPTEGD FLQPGRNQVA AGYAVYGPQT MLVVTLSGGV 190 200 210 220 230 240 NGFTLSADGR WLLTHPDLAI KPDTAEFAIN MSNQRHWAPA VRRYIDGCLQ GKDGARGKNF 250 260 270 280 290 300 NMRWVASMVA DVHRIMMRGG VFMYPWDARE PDKPGKLRLM YEANPMSLLA ERAGGKSIEG 310 320 330 LNEILDINPA KLHQRVPVVL GSANEVEVIR AEMRAG

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23366.1.
PIR	B87421.
RefSeq	NP_420198.1. NC_002696.2.
3D structure databases
HSSP	HSSP built from PDB template 2GQ1 based on UniProtKB P0A993.
ProteinModelPortal	Q9A8G9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	941724.
GenomeReviews	Gene locus CC_1385 in contig AE005673_GR.
KEGG	ccr:CC_1385.
NMPDR	fig|190650.1.peg.1378.
PATRIC	21299788. VBICauCre124313_1415.
TIGR	CC_1385.
Phylogenomic databases
HOGENOM	HBG731261.
OMA	HWEAPVQ.
ProtClustDB	PRK09293.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_CAUCR

Accession

Primary (citable) accession number: Q9A8G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program