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Protein

Uronate isomerase

Gene

uxaC

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.UniRule annotation
D-galacturonate = D-tagaturonate.UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciCAULO:CC1490-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomeraseUniRule annotation (EC:5.3.1.12UniRule annotation)
Alternative name(s):
Glucuronate isomeraseUniRule annotation
Uronic isomeraseUniRule annotation
Gene namesi
Name:uxaCUniRule annotation
Ordered Locus Names:CC_1490
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Uronate isomerasePRO_0000172766Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_1490.

Structurei

Secondary structure

1
487
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni9 – 124Combined sources
Helixi17 – 2812Combined sources
Turni29 – 324Combined sources
Beta strandi35 – 373Combined sources
Helixi45 – 495Combined sources
Helixi56 – 594Combined sources
Helixi65 – 728Combined sources
Turni73 – 753Combined sources
Turni79 – 824Combined sources
Helixi94 – 10310Combined sources
Helixi105 – 1084Combined sources
Helixi112 – 12312Combined sources
Turni133 – 1353Combined sources
Helixi136 – 14712Combined sources
Helixi150 – 1523Combined sources
Helixi154 – 1607Combined sources
Beta strandi163 – 1675Combined sources
Helixi177 – 1848Combined sources
Turni199 – 2013Combined sources
Helixi208 – 21912Combined sources
Helixi226 – 24217Combined sources
Beta strandi247 – 2504Combined sources
Helixi262 – 27413Combined sources
Helixi279 – 30022Combined sources
Beta strandi303 – 3064Combined sources
Helixi316 – 3216Combined sources
Beta strandi324 – 3274Combined sources
Turni337 – 3393Combined sources
Helixi341 – 3477Combined sources
Beta strandi355 – 3573Combined sources
Helixi364 – 3674Combined sources
Helixi369 – 3735Combined sources
Beta strandi379 – 3813Combined sources
Helixi386 – 3883Combined sources
Helixi391 – 40515Combined sources
Helixi420 – 4223Combined sources
Helixi423 – 44321Combined sources
Helixi449 – 46012Combined sources
Helixi462 – 4676Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q01X-ray2.34A/B/C2-487[»]
ProteinModelPortaliQ9A874.
SMRiQ9A874. Positions 3-482.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9A874.

Family & Domainsi

Sequence similaritiesi

Belongs to the uronate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
HOGENOMiHOG000238114.
KOiK01812.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9A874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLSFHED RLFPSDPATR SYARGLYALV KDLPIISPHG HTDPSWFATN
60 70 80 90 100
APFQDATDLL LAPDHYLFRM LYSQGVSLDA LKVRSKAGVP DTDPREAWRV
110 120 130 140 150
FASHFYLFRG TPSWVWLNHV FSQVFGFTEF LEASNADDYF DRITAALATD
160 170 180 190 200
AFRPRALFDR FNIETLATTE GPHESLQHHA AIRESGWGGH VITAYRPDAV
210 220 230 240 250
IDFEDERSPR AFERFAETSG QDVYSWKSYL EAHRLRRQAF IDAGATSSDH
260 270 280 290 300
GHPTAATADL SDVEAEALFN SLVKGDVTPE KAELFRAQML TEMAKMSLDD
310 320 330 340 350
GLVMQIHPGS HRNHNVGLLN SHGRDKGADI PMRTEYVDAL KPLLTRLGND
360 370 380 390 400
PRLSIILFTL DETTYSRELA PLAGHYPVLK LGPSWWFHDS PEGMMRFREQ
410 420 430 440 450
VTETAGFYNT VGFNDDTRAF LSIPARHDVA RRVDSAFLAR MVAEHRMDLV
460 470 480
EAEELIVDLT YNLPKKAYKL DQRPDWARPA TLRAAAE
Length:487
Mass (Da):55,052
Last modified:June 1, 2001 - v1
Checksum:i0FA4C80E085ED4F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK23469.1.
PIRiA87434.
RefSeqiNP_420301.1. NC_002696.2.
WP_010919364.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK23469; AAK23469; CC_1490.
GeneIDi941836.
KEGGiccr:CC_1490.
PATRICi21300000. VBICauCre124313_1517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK23469.1.
PIRiA87434.
RefSeqiNP_420301.1. NC_002696.2.
WP_010919364.1. NC_002696.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q01X-ray2.34A/B/C2-487[»]
ProteinModelPortaliQ9A874.
SMRiQ9A874. Positions 3-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_1490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK23469; AAK23469; CC_1490.
GeneIDi941836.
KEGGiccr:CC_1490.
PATRICi21300000. VBICauCre124313_1517.

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
HOGENOMiHOG000238114.
KOiK01812.
OMAiGHTDPRW.
OrthoDBiEOG6J1D95.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciCAULO:CC1490-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9A874.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiUXAC_CAUCR
AccessioniPrimary (citable) accession number: Q9A874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.