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Protein

Ribonuclease 3

Gene

rnc

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48MagnesiumUniRule annotation1
Active sitei52UniRule annotation1
Active sitei124UniRule annotation1
Metal bindingi124MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC1560-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:CC_1560
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803841 – 231Ribonuclease 3Add BLAST231

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1560

Structurei

3D structure databases

ProteinModelPortaliQ9A805
SMRiQ9A805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 135RNase IIIUniRule annotationAdd BLAST128
Domaini161 – 230DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRVAAVGD LERRIGHRFE DRELLERALT HASVGDGAKK VRDNEVLEFI
60 70 80 90 100
GDRVLGLLAA EALAQRFPKA KEGELAPRLN ALVSRETCAR VARKAELGPA
110 120 130 140 150
LRLSASSSKI GGRETDSILA GATEALMAAL YQDGGLEAAR KVFLDLWNDE
160 170 180 190 200
FDRAGEGRPR DPKTALQEWA QGQGRPLPTY RVLDRTGPDH APVFTVEVSV
210 220 230
TGVDPAIAKG KSRQEAEKAA AKALLEREGA G
Length:231
Mass (Da):24,971
Last modified:June 1, 2001 - v1
Checksum:iB53F777CE9364C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK23539.1
PIRiG87442
RefSeqiNP_420371.1, NC_002696.2
WP_010919434.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK23539; AAK23539; CC_1560
GeneIDi942457
KEGGiccr:CC_1560
PATRICifig|190650.5.peg.1589

Similar proteinsi

Entry informationi

Entry nameiRNC_CAUVC
AccessioniPrimary (citable) accession number: Q9A805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health