Q9A7V7 (PH4H_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phenylalanine-4-hydroxylase
Short name=PAH
EC=1.14.16.1

Alternative name(s):
Phe-4-monooxygenase

Gene names

Name:	phhA
Ordered Locus Names:	CC_1612

Organism

Caulobacter crescentus (Caulobacter vibrioides)

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin.
Cofactor	Binds 1 Fe2+ ion By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.
Sequence similarities	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism
Ligand	Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro phenylalanine 4-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Phenylalanine-4-hydroxylase		PRO_0000205554
Sites
	Metal binding	129	1	Iron Potential
	Metal binding	134	1	Iron Potential
	Metal binding	175	1	Iron Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9A7V7 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A623276FD0506720	FASTA	294	32,761
	10 20 30 40 50 60 MSGDGLSNGP PPGARPDWTI DQGWETYTQA EHDVWITLYE RQTDMLHGRA CDEFMRGLDA 70 80 90 100 110 120 LDLHRSGIPD FARINEELKR LTGWTVVAVP GLVPDDVFFD HLANRRFPAG QFIRKPHELD 130 140 150 160 170 180 YLQEPDIFHD VFGHVPMLTD PVFADYMQAY GEGGRRALGL GRLANLARLY WYTVEFGLMN 190 200 210 220 230 240 TPAGLRIYGA GIVSSRTESI FALDDPSPNR IGFDLERVMR TLYRIDDFQQ VYFVIDSIQT 250 260 270 280 290 LQEVTLRDFG AIYERLASVS DIGVAEIVPG DAVLTRGTQA YATAGGRLAG AAAG

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23591.1.
PIR	C87449.
RefSeq	NP_420423.1. NC_002696.2.
3D structure databases
ProteinModelPortal	Q9A7V7.
SMR	Q9A7V7. Positions 9-275.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	941967.
GenomeReviews	Gene locus CC_1612 in contig AE005673_GR.
KEGG	ccr:CC_1612.
NMPDR	fig|190650.1.peg.1603.
PATRIC	21300246. VBICauCre124313_1639.
TIGR	CC_1612.
Phylogenomic databases
HOGENOM	HBG403840.
OMA	FLARLYW.
ProtClustDB	PRK11913.
Family and domain databases
InterPro	IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005960. Phe-4-hydroxylase_mono. [Graphical view]
Gene3D	G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
KO	K00500.
PANTHER	PTHR11473. Aaa_hydroxylase. 1 hit.
Pfam	PF00351. Biopterin_H. 1 hit. [Graphical view]
PRINTS	PR00372. FYWHYDRXLASE.
SUPFAM	SSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMs	TIGR01267. Phe4hydrox_mono. 1 hit.
PROSITE	PS00367. BH4_AAA_HYDROXYL_1. 1 hit. PS51410. BH4_AAA_HYDROXYL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PH4H_CAUCR

Accession

Primary (citable) accession number: Q9A7V7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program