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Q9A7Q9 (ALR_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:CC_1661
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Alanine racemase HAMAP-Rule MF_01201
PRO_0000114507

Sites

Active site371Proton acceptor; specific for D-alanine By similarity
Active site2571Proton acceptor; specific for L-alanine By similarity
Binding site1351Substrate By similarity
Binding site3051Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue371N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A7Q9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9B35D0A3A41D4CDF

FASTA36438,637
        10         20         30         40         50         60 
MTDAQDTRIT IDLDALAHNY AALRARAGDA EVAPAVKADA YGLGAAPVAD RLWAEGARSF 

        70         80         90        100        110        120 
YVARLAEGVA LRRSLGDREA TIYVLDGATP GSGEALEGAQ LVPVLNSLPQ VEAWNVQARS 

       130        140        150        160        170        180 
GRLRAALHID TGMNRLGLRP EELKVLVGSF DRLKRLDVEL VVSHLACADT PEHPLNATQL 

       190        200        210        220        230        240 
ARFQEAAALL PGVRRSLANS GGLFLGEAYR FDQTRPGVSL YGGGPEGRPH PEIRAVATVE 

       250        260        270        280        290        300 
APILQVRVVP RGESIGYGAG WTASDNTRVA IVAAGYADGV PRAAFPRGEV WFDGARRPML 

       310        320        330        340        350        360 
GRVSMDLIAV DVTDCDAARP GAMVELFGAN LPVDDAADAA GTSAYERLTR LTLRGVRRYV 


GGAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK23639.1.
PIRC87455.
RefSeqNP_420471.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A7Q9.
SMRQ9A7Q9. Positions 8-361.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK23639; AAK23639; CC_1661.
GeneID942015.
KEGGccr:CC_1661.
PATRIC21300348. VBICauCre124313_1690.

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031445.
KOK01775.
OMAPSECAGV.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycCAULO:CC1661-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_CAUCR
AccessionPrimary (citable) accession number: Q9A7Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways