Reviewed, UniProtKB/Swiss-Prot Q9A7N9 (KGUA_CAUCR)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CC_1681

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Guanylate kinase HAMAP MF_00328		PRO_0000170517
Regions
	Domain	10 – 189	180	Guanylate kinase-like
	Nucleotide binding	17 – 24	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A7N9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CA9796C7739EF056	FASTA	213	24,219
	10 20 30 40 50 60 MNKSHHPHRG LLLMVVAPSG VGKTSLTRRL VSDHGDLHLS ISATTRDPRP GEHDGRDYHF 70 80 90 100 110 120 VSRDKFQGML AEDAFLEWAE VYGNFYGSPK APIMDALSRG ESVLFDIDFQ GAMKVHKQAG 130 140 150 160 170 180 ADSVLVYILP PSLAEMSRRL HTRSQDSEEV IHRRLSRAKD EVAAWEQFDY VILNDDFDRA 190 200 210 YADLAHIYHA ERLKRARNPW IGDLVSDLLK EEI

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK23659.1.
PIR	G87457.
RefSeq	NP_420491.1.
3D structure databases
SMR	Q9A7N9. Positions 8-188.
ModBase	Search...
Genome annotation databases
GeneID	942041.
GenomeReviews	Gene locus CC_1681 in contig AE005673_GR.
KEGG	ccr:CC_1681.
NMPDR	fig|190650.1.peg.1671.
TIGR	CC_1681.
Phylogenomic databases
HOGENOM	HBG671982.
OMA	DIDWQGT.
Enzyme and pathway databases
BRENDA	2.7.4.8. 2191.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CAUCR

Accession

Primary (citable) accession number: Q9A7N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)