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Q9A7N4 (PDXA_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:CC_1686
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3333334-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_0000188803

Sites

Metal binding1691Divalent metal cation; shared with dimeric partner By similarity
Metal binding2141Divalent metal cation; shared with dimeric partner By similarity
Metal binding2691Divalent metal cation; shared with dimeric partner By similarity
Binding site1331Substrate By similarity
Binding site1341Substrate By similarity
Binding site2771Substrate By similarity
Binding site2861Substrate By similarity
Binding site2951Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9A7N4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0C6689D5E267D112

FASTA33334,206
        10         20         30         40         50         60 
MTSRPLAISA GDPAGVGAEI IAKAWRALRQ DGPTFVVIGD AQLLASAGGG VKVRAVTRPQ 

        70         80         90        100        110        120 
EAAQVFPDAL PVLDIPVLSP VVYGRPSPSH APQIIRWIET GVGLALSGAV SGLVTAPIAK 

       130        140        150        160        170        180 
APLYEAGFQF PGHTEFLAEL TAAASMVGAR GPVMMLAAGD LRATLVTIHT ALAKAPSALT 

       190        200        210        220        230        240 
TEAIINSGLV TAQALRKDFG IAEPRLAVAA LNPHAGEGGA LGREEIDIIA PAVEALRALG 

       250        260        270        280        290        300 
VQASGPAPAD TLFHPEARAR YDGVLCMYHD QALIPVKMLD FWGGVNITLG LPIVRTSPDH 

       310        320        330 
GTGFDIAGRG IARPDSLIAA IQLAAKIAAR RGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK23664.1.
PIRD87458.
RefSeqNP_420496.1. NC_002696.2.

3D structure databases

ProteinModelPortalQ9A7N4.
SMRQ9A7N4. Positions 3-328.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK23664; AAK23664; CC_1686.
GeneID941101.
KEGGccr:CC_1686.
PATRIC21300398. VBICauCre124313_1715.

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221593.
KOK00097.
OMAYVWDTPL.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK05312.

Enzyme and pathway databases

BioCycCAULO:CC1686-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_CAUCR
AccessionPrimary (citable) accession number: Q9A7N4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways