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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Metal bindingi169Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi214Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi269Divalent metal cation; shared with dimeric partnerUniRule annotation1
Binding sitei277SubstrateUniRule annotation1
Binding sitei286SubstrateUniRule annotation1
Binding sitei295SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandCobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciCAULO:CC1686-MONOMER
UniPathwayiUPA00244; UER00312

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:CC_1686
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001888031 – 3334-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST333

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1686

Structurei

3D structure databases

ProteinModelPortaliQ9A7N4
SMRiQ9A7N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221593
KOiK00097
OMAiAPVHKGV

Family and domain databases

HAMAPiMF_00536 PdxA, 1 hit
InterProiView protein in InterPro
IPR037510 PdxA
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A7N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRPLAISA GDPAGVGAEI IAKAWRALRQ DGPTFVVIGD AQLLASAGGG
60 70 80 90 100
VKVRAVTRPQ EAAQVFPDAL PVLDIPVLSP VVYGRPSPSH APQIIRWIET
110 120 130 140 150
GVGLALSGAV SGLVTAPIAK APLYEAGFQF PGHTEFLAEL TAAASMVGAR
160 170 180 190 200
GPVMMLAAGD LRATLVTIHT ALAKAPSALT TEAIINSGLV TAQALRKDFG
210 220 230 240 250
IAEPRLAVAA LNPHAGEGGA LGREEIDIIA PAVEALRALG VQASGPAPAD
260 270 280 290 300
TLFHPEARAR YDGVLCMYHD QALIPVKMLD FWGGVNITLG LPIVRTSPDH
310 320 330
GTGFDIAGRG IARPDSLIAA IQLAAKIAAR RGV
Length:333
Mass (Da):34,206
Last modified:June 1, 2001 - v1
Checksum:i0C6689D5E267D112
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK23664.1
PIRiD87458
RefSeqiNP_420496.1, NC_002696.2
WP_010919557.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK23664; AAK23664; CC_1686
GeneIDi941101
KEGGiccr:CC_1686
PATRICifig|190650.5.peg.1715

Similar proteinsi

Entry informationi

Entry nameiPDXA_CAUVC
AccessioniPrimary (citable) accession number: Q9A7N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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