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Protein

Thiazole synthase

Gene

thiG

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112Schiff-base intermediate with DXPUniRule annotation1
Binding sitei173DXP; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processThiamine biosynthesis
LigandSchiff base

Enzyme and pathway databases

BioCyciCAULO:CC1880-MONOMER
UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiazole synthaseUniRule annotation (EC:2.8.1.10UniRule annotation)
Gene namesi
Name:thiGUniRule annotation
Ordered Locus Names:CC_1880
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001628031 – 269Thiazole synthaseAdd BLAST269

Interactioni

Subunit structurei

Homotetramer. Forms heterodimers with either ThiH or ThiS.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_1880

Structurei

3D structure databases

ProteinModelPortaliQ9A746
SMRiQ9A746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 200DXP bindingUniRule annotation2
Regioni221 – 222DXP bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ThiG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CA8 Bacteria
COG2022 LUCA
HOGENOMiHOG000248049
KOiK03149
OMAiAQYPSPA

Family and domain databases

CDDicd04728 ThiG, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00443 ThiG, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033983 Thiazole_synthase_ThiG
IPR008867 ThiG
PANTHERiPTHR34266 PTHR34266, 1 hit
PfamiView protein in Pfam
PF05690 ThiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHVTPDSV TADSDETWTV AGRTFRSRLI VGTGKYKDYA TNAAAARAAG
60 70 80 90 100
AEIVTVAVRR VNLTDPSQPL LVDYVKPTEF TYLPNTAGCF TGEDAVRTLR
110 120 130 140 150
LAREAGGWDL VKLEVLSDPK TLFPDMEETL RSLKLLVADG FQVMVYCSDD
160 170 180 190 200
PVYARKLEEA GAVAIMPLGA PIGSGLGIQN RVNLRIIIEN AKVPVLVDAG
210 220 230 240 250
VGTASDAAIG MELGCDAILM NTAIAEAKDP IRMAKAMKHA VIAGREAYLA
260
GRMQKRLYAD PSSPLAGLI
Length:269
Mass (Da):28,707
Last modified:June 1, 2001 - v1
Checksum:i96E557ACC69BA922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK23855.1
PIRiC87482
RefSeqiNP_420687.1, NC_002696.2
WP_010919746.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK23855; AAK23855; CC_1880
GeneIDi942361
KEGGiccr:CC_1880
PATRICifig|190650.5.peg.1897

Similar proteinsi

Entry informationi

Entry nameiTHIG_CAUVC
AccessioniPrimary (citable) accession number: Q9A746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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