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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCAULO:CC2056-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Ordered Locus Names:CC_2056
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900901 – 2326-phosphogluconolactonaseAdd BLAST232

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_2056.

Structurei

3D structure databases

ProteinModelPortaliQ9A6N1.
SMRiQ9A6N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
HOGENOMiHOG000256284.
KOiK01057.
OMAiKQPHLAI.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9A6N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFTPIKLEA FGSREDLYDA AASVLVGALT TAVARHGRVG FAATGGTTPA
60 70 80 90 100
PVYDRMATMT APWDKVTVTL TDERFVPATD ASSNEGLVRR HLLVGEAAKA
110 120 130 140 150
SFAPLFFDGV SHDESARKAE AGVNAATPFG VVLLGVGPDG HFASLFPGNP
160 170 180 190 200
MLDQGLDLAT DRSVLAVPPS DPAPDLPRLS LTLAALTRTD LIVLLVTGAA
210 220 230
KKALLDGDVD PALPVAAILK QDRAKVRILW AE
Length:232
Mass (Da):24,234
Last modified:June 1, 2001 - v1
Checksum:i8FBEA52F720F87B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24029.1.
PIRiA87504.
RefSeqiNP_420861.1. NC_002696.2.
WP_010919919.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK24029; AAK24029; CC_2056.
GeneIDi942979.
KEGGiccr:CC_2056.
PATRICi21301128. VBICauCre124313_2075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24029.1.
PIRiA87504.
RefSeqiNP_420861.1. NC_002696.2.
WP_010919919.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9A6N1.
SMRiQ9A6N1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_2056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK24029; AAK24029; CC_2056.
GeneIDi942979.
KEGGiccr:CC_2056.
PATRICi21301128. VBICauCre124313_2075.

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
HOGENOMiHOG000256284.
KOiK01057.
OMAiKQPHLAI.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciCAULO:CC2056-MONOMER.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_CAUCR
AccessioniPrimary (citable) accession number: Q9A6N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.