Reviewed, UniProtKB/Swiss-Prot Q9A6B1 (MSRB_CAUCR)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	CC_2183

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity. HAMAP MF_01400
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_0000140266
Sites
	Active site	133	1	Nucleophile By similarity
	Metal binding	61	1	Zinc By similarity
	Metal binding	64	1	Zinc By similarity
	Metal binding	110	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A6B1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2DCFA741AF36EE57	FASTA	159	17,300
	10 20 30 40 50 60 MTDAATLSTA GFDLTPPTEA ERERLEANLT AEEARVLLHH GTEAPFCGGL LGEKSPGVYG 70 80 90 100 110 120 CRLCGLPLFK HETKFESGTG WPSFYAPFAE DHVVGVRDTS YGMVRIETRC ARCDSHQGHV 130 140 150 FPDGPAPTRL RYCINSVSLQ FVKAGAPLPD PLHRGDKIT

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005673 Genomic DNA. Translation: AAK24154.1.
PIR	F87519.
RefSeq	NP_420986.1.
3D structure databases
SMR	Q9A6B1. Positions 22-146.
ModBase	Search...
Genome annotation databases
GeneID	943108.
GenomeReviews	Gene locus CC_2183 in contig AE005673_GR.
KEGG	ccr:CC_2183.
NMPDR	fig|190650.1.peg.2166.
TIGR	CC_2183.
Phylogenomic databases
HOGENOM	HBG715255.
OMA	CCRLCAL.
Enzyme and pathway databases
BRENDA	1.8.4.12. 2191.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_CAUCR

Accession

Primary (citable) accession number: Q9A6B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)