Reviewed, UniProtKB/Swiss-Prot Q9A671 (HIS81_CAUCR)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	CC_2223

Organism

Caulobacter crescentus (Caulobacter vibrioides) [Complete proteome] [HAMAP]

Taxonomic identifier

155892 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153342
Amino acid modifications
	Modified residue	216	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9A671-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A2EFE47EDA0B6C65	FASTA	359	39,262
	10 20 30 40 50 60 MPKPGIMDIH AYVGGKSKVE GIAHPVKLSS NENILGSSDK AKDAYRNAVD RLHIYPDGKA 70 80 90 100 110 120 NFLRAAVAER YKLEPERLTF GDGSDEIFAL LCQVYLEPGD NIVQGEHGFA AYAIGARACQ 130 140 150 160 170 180 GEVRMAKEVN HRVDIDEVIK CVDERTRLVF IANPANPTGT WLTGEEIRAL HAALPPSVVL 190 200 210 220 230 240 VLDGAYAEFC SDPHFEDGLE LARTAENVIV TRTFSKIHGL AALRVGWGYA PEHIIAPIER 250 260 270 280 290 300 IRPPFNTSIP AQEAAVAALF DDDFQDRSRA LVEQWRPWLA QQLGGLGLEV TPSAANFVLA 310 320 330 340 350 TFPTTPGKTA PEAEAFLASK GYLVRAVGNY NLPHAIRITI GLEEQNRAVV ELLSQFMGR

References

[1]

"Complete genome sequence of Caulobacter crescentus." Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J. , Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001) [PubMed: 11259647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19089 / CB15.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005673 Genomic DNA. Translation: AAK24194.1.
PIR	F87524.
RefSeq	NP_421026.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	943147.
GenomeReviews	Gene locus CC_2223 in contig AE005673_GR.
KEGG	ccr:CC_2223.
NMPDR	fig|190650.1.peg.2206.
TIGR	CC_2223.
Phylogenomic databases
HOGENOM	Q9A671.
OMA	GFLVYKI.
Enzyme and pathway databases
BRENDA	2.6.1.9. 2191.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_CAUCR

Accession

Primary (citable) accession number: Q9A671

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)