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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151NucleophileUniRule annotation
Metal bindingi15 – 151MagnesiumUniRule annotation
Metal bindingi17 – 171MagnesiumUniRule annotation
Metal bindingi177 – 1771MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC2305-MONOMER.
UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:CC_2305
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Phosphoglycolate phosphatasePRO_0000108026Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_2305.

Structurei

3D structure databases

ProteinModelPortaliQ9A5Z2.
SMRiQ9A5Z2. Positions 12-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiSANACFR.
OrthoDBiEOG6HB9PJ.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_00495. GPH_hydrolase_bact.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01449. PGP_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9A5Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLHDLNGA TIAFDLDGTL VDTAPDLVGA LNIILAQESL PPLPFDDVRL
60 70 80 90 100
MVGRGARALL ERGFAAAGAP LDAEQAPALV QRFIDVYLAR IADESAPFPG
110 120 130 140 150
VVEVLSDLKT AGAKLVVCTN KLTNLSTALL DAVALSPFFE AVIGADLAPA
160 170 180 190 200
AKPDGRHVAA AVAAVGGDVS RAVMIGDSVN DALGARNAGV PGVLVSFGYT
210 220 230
EEPVETLGAD LVIHSFLDVP KACITLLTSC PAPNTGL
Length:237
Mass (Da):24,219
Last modified:June 1, 2001 - v1
Checksum:i6C3B2E48485D013F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24276.1.
PIRiH87534.
RefSeqiNP_421108.1. NC_002696.2.
WP_010920164.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK24276; AAK24276; CC_2305.
GeneIDi943469.
KEGGiccr:CC_2305.
PATRICi21301634. VBICauCre124313_2324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24276.1.
PIRiH87534.
RefSeqiNP_421108.1. NC_002696.2.
WP_010920164.1. NC_002696.2.

3D structure databases

ProteinModelPortaliQ9A5Z2.
SMRiQ9A5Z2. Positions 12-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_2305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK24276; AAK24276; CC_2305.
GeneIDi943469.
KEGGiccr:CC_2305.
PATRICi21301634. VBICauCre124313_2324.

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiSANACFR.
OrthoDBiEOG6HB9PJ.

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.
BioCyciCAULO:CC2305-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_00495. GPH_hydrolase_bact.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01449. PGP_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiGPH_CAUCR
AccessioniPrimary (citable) accession number: Q9A5Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.