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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15NucleophileUniRule annotation1
Metal bindingi15MagnesiumUniRule annotation1
Metal bindingi17MagnesiumUniRule annotation1
Metal bindingi177MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAULO:CC2305-MONOMER
UniPathwayiUPA00865; UER00834

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:CC_2305
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080261 – 237Phosphoglycolate phosphataseAdd BLAST237

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_2305

Structurei

3D structure databases

ProteinModelPortaliQ9A5Z2
SMRiQ9A5Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP Bacteria
COG0546 LUCA
HOGENOMiHOG000248344
KOiK01091
OMAiYLCGKFG

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00495 GPH_hydrolase_bact, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR006346 PGPase/MupP
IPR037512 PGPase_prok
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01449 PGP_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q9A5Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLHDLNGA TIAFDLDGTL VDTAPDLVGA LNIILAQESL PPLPFDDVRL
60 70 80 90 100
MVGRGARALL ERGFAAAGAP LDAEQAPALV QRFIDVYLAR IADESAPFPG
110 120 130 140 150
VVEVLSDLKT AGAKLVVCTN KLTNLSTALL DAVALSPFFE AVIGADLAPA
160 170 180 190 200
AKPDGRHVAA AVAAVGGDVS RAVMIGDSVN DALGARNAGV PGVLVSFGYT
210 220 230
EEPVETLGAD LVIHSFLDVP KACITLLTSC PAPNTGL
Length:237
Mass (Da):24,219
Last modified:June 1, 2001 - v1
Checksum:i6C3B2E48485D013F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK24276.1
PIRiH87534
RefSeqiNP_421108.1, NC_002696.2
WP_010920164.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK24276; AAK24276; CC_2305
GeneIDi943469
KEGGiccr:CC_2305
PATRICifig|190650.5.peg.2324

Similar proteinsi

Entry informationi

Entry nameiGPH_CAUVC
AccessioniPrimary (citable) accession number: Q9A5Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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